伤害
(+)-纳洛酮
药理学
热板试验
化学
格列本脲
转子性能试验
戊巴比妥
克罗马卡林
乙醇
开阔地
麻醉
医学
类阿片
内分泌学
运动活动
生物化学
受体
糖尿病
作者
Jiang Hu,Xiaodong Shi,Xia Mao,Jiangang Chen,Lei Zhu,Qingjie Zhao
标识
DOI:10.1016/j.jep.2013.04.035
摘要
Antinociceptive activity of Rhoifoline A (RA), a benzophenanthridine alkaloid obtained from the ethanol extract of Zanthoxylum nitidum, was evaluated in mice using chemical and thermal models of nociception. RA was evaluated on anti-nociceptive activity in mice using chemical and thermal models of nociception. RA administered intraperitoneally at doses of 10, 20, 40 and 80 mg/kg exhibited significant inhibitions on chemical nociception induced by intraperitoneal acetic acid and subplantar formalin, and on thermal nociception in the tail-flick test and the hot plate test. RA neither significantly impaired motor coordination in the rotarod test nor did spontaneous locomotion in the open-field test. RA did not enhance the pentobarbital sodium induced sleep time. These results indicated that the observed antinociceptive activity of RA was unrelated to sedation or motor abnormality. Core body temperature measurement showed that RA did not affect temperature during a 2-hour period. Furthermore, RA-induced antinociception in the hot plate test was insensitive to naloxone or glibenclamide but significantly antagonized by L-NAME, methylene blue and nimodipine. Therefore, it is reasonable that the analgesic mechanism of RA possibly involved the NO-cGMP signaling pathway and L-type Ca2+ channels.
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