薯蓣皂甙元
癌症研究
细胞迁移
转移
细胞
乳腺癌
化学
癌症
体外
药理学
生物
内科学
医学
生物化学
有机化学
作者
Zhongmei He,Hongyan Chen,Guofeng Li,Hong-Yan Zhu,Yugang Gao,Lianxue Zhang,Jiaming Sun
出处
期刊:Phytomedicine
[Elsevier]
日期:2014-05-01
卷期号:21 (6): 871-876
被引量:73
标识
DOI:10.1016/j.phymed.2014.02.002
摘要
Diosgenin, a naturally occurring steroidal saponin, possess tumor therapeutic potential. However, the effect of diosgenin on cancer metastasis remains poorly understood. In this study, we performed in vitro experiments to investigate the inhibitory activity of diosgenin on human breast cancer MDA-MB-231 cell migration, and reveal the possible mechanism. Diosgenin caused a marked inhibition of cell migration in MDA-MB-231 cell by transwell assay. In addition, diosgenin significantly impacted MDA-MB-231 cell migratory behavior under real-time observation. We also found diosgenin significantly inhibited actin polymerization, Vav2 phosphorylation and Cdc42 activation, which might be, at least in part, attributed to the anti-metastatic potential of diosgenin. These findings reveal a new therapeutic potential of diosgenin for human breast cancer metastasis therapy.
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