气溶胶化
药物输送
药品
脂质体
前药
生物相容性
微球
药理学
靶向给药
纳米技术
生物医学工程
医学
材料科学
吸入
麻醉
冶金
工程类
化学工程
作者
Gaurav Tiwari,Ruchi Tiwari,S. Bannerjee,Lokesh Bhati,Suneel Pandey,Poonam Pandey,Birendra Sriwastawa
出处
期刊:International journal of pharmaceutical investigation
[EManuscript Services]
日期:2012-01-01
卷期号:2 (1): 2-2
被引量:1197
标识
DOI:10.4103/2230-973x.96920
摘要
Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. For the treatment of human diseases, nasal and pulmonary routes of drug delivery are gaining increasing importance. These routes provide promising alternatives to parenteral drug delivery particularly for peptide and protein therapeutics. For this purpose, several drug delivery systems have been formulated and are being investigated for nasal and pulmonary delivery. These include liposomes, proliposomes, microspheres, gels, prodrugs, cyclodextrins, among others. Nanoparticles composed of biodegradable polymers show assurance in fulfilling the stringent requirements placed on these delivery systems, such as ability to be transferred into an aerosol, stability against forces generated during aerosolization, biocompatibility, targeting of specific sites or cell populations in the lung, release of the drug in a predetermined manner, and degradation within an acceptable period of time.
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