虫草素
蛹虫草
冬虫夏草
瓶子
发酵
液体培养
化学
食品科学
生物
植物
材料科学
复合材料
作者
Chao Kang,Ting-Chi Wen,Ji-Chuan Kang,Ze-Bing Meng,Guangrong Li,Kevin D. Hyde
摘要
Cordycepin is one of the most important bioactive compounds produced by species of Cordyceps sensu lato , but it is hard to produce large amounts of this substance in industrial production. In this work, single factor design, Plackett-Burman design, and central composite design were employed to establish the key factors and identify optimal culture conditions which improved cordycepin production. Using these culture conditions, a maximum production of cordycepin was 2008.48 mg/L for 700 mL working volume in the 1000 mL glass jars and total content of cordycepin reached 1405.94 mg/bottle. This method provides an effective way for increasing the cordycepin production at a large scale. The strategies used in this study could have a wide application in other fermentation processes.
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