坏死性下垂
裂谷1
多发性硬化
少突胶质细胞
程序性细胞死亡
神经退行性变
促炎细胞因子
生物
肿瘤坏死因子α
疾病
细胞凋亡
癌症研究
免疫学
炎症
医学
神经科学
病理
中枢神经系统
髓鞘
生物化学
作者
Dimitry Ofengeim,Yasushi Itoh,Ayaz Najafov,Yaoyang Zhang,Bing Shan,Judy Park DeWitt,Juanying Ye,Xumin Zhang,Ansi Chang,Helin Vakifahmetoglu-Norberg,Jiefei Geng,Bénédicte F. Py,Wen Zhou,Palak Amin,Jonilson Berlink Lima,Chunting Qi,Qiang Yu,Bruce D. Trapp,Junying Yuan
出处
期刊:Cell Reports
[Elsevier]
日期:2015-03-01
卷期号:10 (11): 1836-1849
被引量:443
标识
DOI:10.1016/j.celrep.2015.02.051
摘要
Summary
Multiple sclerosis (MS), a common neurodegenerative disease of the CNS, is characterized by the loss of oligodendrocytes and demyelination. Tumor necrosis factor α (TNF-α), a proinflammatory cytokine implicated in MS, can activate necroptosis, a necrotic cell death pathway regulated by RIPK1 and RIPK3 under caspase-8-deficient conditions. Here, we demonstrate defective caspase-8 activation, as well as activation of RIPK1, RIPK3, and MLKL, the hallmark mediators of necroptosis, in the cortical lesions of human MS pathological samples. Furthermore, we show that MS pathological samples are characterized by an increased insoluble proteome in common with other neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD). Finally, we show that necroptosis mediates oligodendrocyte degeneration induced by TNF-α and that inhibition of RIPK1 protects against oligodendrocyte cell death in two animal models of MS and in culture. Our findings demonstrate that necroptosis is involved in MS and suggest that targeting RIPK1 may represent a therapeutic strategy for MS.
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