One-Pot, Two-Step Direct Conversion of Alkenes to Amines Through Tandem Ozonolysis and Ammonia-Borane in Water

Abstract Abstract An efficient, one-pot, two-step reductive amination of alkenes through tandem ozonolysis using ammonia-borane as a reducing agent is described. The reaction has been carried out in water. This is a highly efficient and mild procedure that is applicable to a wide variety of amine substrates. In particular, this is the first successful manifestation that this type of reaction can be carried out in water with ammonia-borane. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] GRAPHICAL ABSTRACT Keywords: Alkenesaminesammonia-borane; ozonewater ACKNOWLEDGMENTS Vipin Tyagi is thankful to Ch. Charan Singh University, Meerut (Uttar Pradesh), India, for providing necessary research facilities. We are grateful to the Sophisticated Analytical Instrumentation Facility (SAIF), Panjab University, Chandigargh, India, especially Avatar Singh, for providing analytical and spectral data.