头盖骨
骨溶解
医学
体内
吸收
骨吸收
牙科
体外
病理
内科学
化学
生物化学
生物
生物技术
作者
David A. Bichara,Erik Malchau,Nanna H. Sillesen,Selami Cakmak,G. Petur Nielsen,Orhun K. Muratoglu
标识
DOI:10.1016/j.arth.2014.03.044
摘要
Recent in vitro findings suggest that UHMWPE wear particles containing vitamin E (VE) may have reduced biologic activity and decreased osteolytic potential. We hypothesized that particles from VE-stabilized, radiation cross-linked UHMWPE would cause less osteolysis in a murine calvarial bone model when compared to virgin gamma irradiated cross-linked UHMWPE. Groups received equal amount of particulate debris overlaying the calvarium for 10 days. Calvarial bone was examined using high resolution micro-CT and histomorphometric analyses. There was a statistically significant difference between virgin (12.2%±8%) and VE-UHMWPE (3%±1.4%) groups in regards to bone resorption (P=0.005) and inflammatory fibrous tissue overlaying the calvaria (0.48 vs. 0.20, P<0.0001). These results suggest that VE-UHMWPE particles have reduced osteolytic potential in vivo when compared to virgin UHMWPE.
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