摘要
HomeStrokeVol. 12, No. 6Thresholds in cerebral ischemia - the ischemic penumbra. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAbstractPDF/EPUBThresholds in cerebral ischemia - the ischemic penumbra. J Astrup, B K Siesjö and L Symon J AstrupJ Astrup Search for more papers by this author , B K SiesjöB K Siesjö Search for more papers by this author and L SymonL Symon Search for more papers by this author Originally published1 Nov 1981https://doi.org/10.1161/01.STR.12.6.723Stroke. 1981;12:723–725 Previous Back to top Next FiguresReferencesRelatedDetailsCited By Rosenblatt K (2023) Reducing Risk for Perioperative Stroke Evidence-Based Practice of Anesthesiology, 10.1016/B978-0-323-77846-6.00005-7, (30-48), . Honarpisheh P, Bryan R and McCullough L (2022) Aging Microbiota-Gut-Brain Axis in Stroke Risk and Outcome, Circulation Research, 130:8, (1112-1144), Online publication date: 15-Apr-2022. Msayib Y, Harston G, Ray K, Larkin J, Sutherland B, Sheerin F, Blockley N, Okell T, Jezzard P, Baldwin A, Sibson N, Kennedy J and Chappell M (2022) Quantitative chemical exchange saturation transfer imaging of nuclear overhauser effects in acute ischemic stroke, Magnetic Resonance in Medicine, 10.1002/mrm.29187, 88:1, (341-356), Online publication date: 1-Jul-2022. Motolese F, Capone F and Di Lazzaro V (2022) New tools for shaping plasticity to enhance recovery after stroke Neuroplasticity - From Bench to Bedside, 10.1016/B978-0-12-819410-2.00016-3, (299-315), . Ding P, Chen W, Yan X, Zhang J, Li C, Zhang G, Wang Y and Li Y (2021) BMPER alleviates ischemic brain injury by protecting neurons and inhibiting neuroinflammation via Smad3‐Akt‐Nrf2 pathway, CNS Neuroscience & Therapeutics, 10.1111/cns.13782, 28:4, (593-607), Online publication date: 1-Apr-2022. Scheldeman L, Wouters A and Lemmens R (2021) Imaging selection for reperfusion therapy in acute ischemic stroke beyond the conventional time window, Journal of Neurology, 10.1007/s00415-021-10872-4, 269:3, (1715-1723), Online publication date: 1-Mar-2022. Wassélius J, Arnberg F, Euler M, Wester P and Ullberg T (2022) Endovascular thrombectomy for acute ischemic stroke, Journal of Internal Medicine, 10.1111/joim.13425, 291:3, (303-316), Online publication date: 1-Mar-2022. Wang W, Li J and Liu J (2022) The Novel microRNA Rno-miR-686-3p Is Associated with the Ischaemic Penumbra, European Neurology, 10.1159/000521491, 85:3, (224-234), . Tomasetti L, Hollesli L, Engan K, Kurz K, Kurz M and Khanmohammadi M Machine Learning Algorithms Versus Thresholding to Segment Ischemic Regions in Patients With Acute Ischemic Stroke, IEEE Journal of Biomedical and Health Informatics, 10.1109/JBHI.2021.3097591, 26:2, (660-672) Jin H, Ma Q, Zhu J, Zang Y, Zhou Y, Xue B, Yang D, Sun C, Gao J, Xu L and Zhang B (2022) A case report of acute testicular pain secondary to segmental testicular infarction, BMC Urology, 10.1186/s12894-022-01006-7, 22:1, Online publication date: 1-Dec-2022. Spiteri A, Wishart C, Pamphlett R, Locatelli G and King N (2021) Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function, Acta Neuropathologica, 10.1007/s00401-021-02384-2, 143:2, (179-224), Online publication date: 1-Feb-2022. Zhu H, Chen Y, Tang T, Ma G, Zhou J, Zhang J, Lu S, Wu F, Luo L, Liu S, Ju S and Shi H (2022) ISP-Net: Fusing features to predict ischemic stroke infarct core on CT perfusion maps, Computer Methods and Programs in Biomedicine, 10.1016/j.cmpb.2022.106630, 215, (106630), Online publication date: 1-Mar-2022. Alkhachroum A, Kromm J and De Georgia M (2022) Big data and predictive analytics in neurocritical care, Current Neurology and Neuroscience Reports, 10.1007/s11910-022-01167-w, 22:1, (19-32), Online publication date: 1-Jan-2022. Chisci E, Lazzeri E, Masciello F, Troisi N, Turini F, Sapio P, Tramacere L, Cincotta M, Fortini A, Baruffi C and Michelagnoli S (2022) Timing to Carotid Endarterectomy Affects Early and Long Term Outcomes of Symptomatic Carotid Stenosis., Annals of Vascular Surgery, 10.1016/j.avsg.2021.10.071, 82, (314-324), Online publication date: 1-May-2022. Chabanne R, Begard M, Guyot A and Moreno R (2022) Anesthésie des patients lors de thrombectomie vasculaire cérébrale, Anesthésie & Réanimation, 10.1016/j.anrea.2022.05.006, Online publication date: 1-Jun-2022. Robba C, Giovannini M, Meyfroidt G, van der Jagt M, Citerio G and Smith M (2021) Intensive Care Admission and Management of Patients With Acute Ischemic Stroke: A Cross-sectional Survey of the European Society of Intensive Care Medicine, Journal of Neurosurgical Anesthesiology, 10.1097/ANA.0000000000000761, 34:3, (313-320), Online publication date: 1-Jul-2022. Shewmon D and Salamon N (2021) The MRI of Jahi McMath and Its Implications for the Global Ischemic Penumbra Hypothesis, Journal of Child Neurology, 10.1177/08830738211035871, 37:1, (35-42), Online publication date: 1-Jan-2022. Mechtouff L, Eker O, Nighoghossian N and Cho T (2022) Fisiopatologia dell’ischemia cerebrale, EMC - Neurologia, 10.1016/S1634-7072(22)46428-2, 22:2, (1-9), Online publication date: 1-Jun-2022. Pan Y, Wu D, Liang H, Tang G, Fan C, Shi L, Ye W and Li M (2021) Total Saponins of Panax notoginseng Activate Akt/mTOR Pathway and Exhibit Neuroprotection in vitro and in vivo against Ischemic Damage, Chinese Journal of Integrative Medicine, 10.1007/s11655-021-3454-y, 28:5, (410-418), Online publication date: 1-May-2022. Doig D and Brown M (2022) Acute stroke care and management of carotid artery stenosis Pathy's Principles and Practice of Geriatric Medicine, 10.1002/9781119484288.ch47, (598-618), Online publication date: 15-Apr-2022. Keep R, Xiang J, Zhou N and Andjelkovic A (2022) The Blood-Brain Barrier in Stroke and Trauma and How to Enhance Drug Delivery Drug Delivery to the Brain, 10.1007/978-3-030-88773-5_23, (699-722), . Gomez C, French B, Siddiq F and Qureshi A (2022) Triage of Stroke Patients for Urgent Intervention Neurointervention in the Medical Specialties, 10.1007/978-3-030-87428-5_6, (73-91), . Liu Y, De Feyter H, Fulbright R, McIntyre S, Nixon T and Graaf R (2022) Interleaved fluid‐attenuated inversion recovery ( FLAIR ) MRI and deuterium metabolic imaging ( DMI ) on human brain in vivo , Magnetic Resonance in Medicine, 10.1002/mrm.29196, 88:1, (28-37), Online publication date: 1-Jul-2022. Zhou X, Zhang Y, Li F, Zhang Z, Cui L, He H, Yan X, He W, Sun H, Feng Z, Chu S and Chen N (2021) Neuronal chemokine-like-factor 1 (CKLF1) up-regulation promotes M1 polarization of microglia in rat brain after stroke, Acta Pharmacologica Sinica, 10.1038/s41401-021-00746-w, 43:5, (1217-1230), Online publication date: 1-May-2022. Alves R, Henriques R, Kerkelä L, Chavarrías C, Jespersen S and Shemesh N (2022) Correlation Tensor MRI deciphers underlying kurtosis sources in stroke, NeuroImage, 10.1016/j.neuroimage.2021.118833, 247, (118833), Online publication date: 1-Feb-2022. Nakka V, Gogada R, Simhadri P, Qadeer M and Phanithi P (2022) Post-treatment with apocynin at a lower dose regulates the UPR branch of eIF2α and XBP-1 pathways after stroke, Brain Research Bulletin, 10.1016/j.brainresbull.2022.02.003, 182, (1-11), Online publication date: 1-May-2022. An H, Goyal M and Powers W (2022) 15O PET Imaging: Methods and Applications Hybrid PET/MR Neuroimaging, 10.1007/978-3-030-82367-2_18, (197-216), . Powers W, An H and Diringer M (2022) Cerebral Blood Flow and Metabolism Stroke, 10.1016/B978-0-323-69424-7.00003-X, (24-41.e8), . Auer R and Sommer C (2022) Histopathology of Brain Tissue Response to Stroke and Injury Stroke, 10.1016/B978-0-323-69424-7.00004-1, (42-56.e2), . Quispe‐Orozco D, Sequeiros J, Farooqui M, Zevallos C, Mendez‐Ruiz A, Dajles A, Kobsa J, Prasad A, Petersen N and Ortega‐Gutierrez S (2022) Stroke Severity and Early Ischemic Changes Predict Infarct Growth Rate and Clinical Outcomes in Patients With Large‐Vessel Occlusion, Stroke: Vascular and Interventional Neurology, 2:4, Online publication date: 1-Jul-2022.Li Z and Cipolla M (2021) Mechanisms of Flow-Mediated Dilation of Pial Collaterals and the Effect of Hypertension, Hypertension, 79:2, (457-467), Online publication date: 1-Feb-2022.Simonsen C, Leslie-Mazwi T and Thomalla G (2020) Which Imaging Approach Should Be Used for Stroke of Unknown Time of Onset?, Stroke, 52:1, (373-380), Online publication date: 1-Jan-2021.Lyden P (2021) Cerebroprotection for Acute Ischemic Stroke: Looking Ahead, Stroke, 52:9, (3033-3044), Online publication date: 1-Sep-2021. Sekine T, Murai Y, Orita E, Ando T, Takagi R, Amano Y, Matano F, Iwata K, Ogawa M, Obara M and Kumita S (2021)(2021) Cross-Comparison of 4-Dimensional Flow Magnetic Resonance Imaging and Intraoperative Middle Cerebral Artery Pressure Measurements Before and After Superficial Temporal Artery-Middle Cerebral Artery Bypass Surgery, Neurosurgery, 10.1093/neuros/nyab305, 89:5, (909-916), Online publication date: 1-Nov-2021. MROSK F, HECHT N and VAJKOCZY P Decompressive hemicraniectomy in ischemic stroke, Journal of Neurosurgical Sciences, 10.23736/S0390-5616.20.05103-6, 65:3 Heiss W and Zaro-Weber O (2021) PET Reveals Pathophysiology in Ischemic Stroke PET and SPECT in Neurology, 10.1007/978-3-030-53168-3_23, (651-671), . Gu Y, Gao H, Kim K, Liu Y, Ramos‐Estebanez C, Luo Y, Wang Y and Yu X (2020) Dynamic oxygen‐17 MRI with adaptive temporal resolution using golden‐means‐based 3D radial sampling, Magnetic Resonance in Medicine, 10.1002/mrm.28636, 85:6, (3112-3124), Online publication date: 1-Jun-2021. Paul S and Candelario-Jalil E (2021) Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies, Experimental Neurology, 10.1016/j.expneurol.2020.113518, 335, (113518), Online publication date: 1-Jan-2021. Grotta J (2021) Fifty Years of Acute Ischemic Stroke Treatment: A Personal History, Cerebrovascular Diseases, 10.1159/000519843, 50:6, (666-680), . Kawase H, Takeda Y, Mizoue R, Sato S, Fushimi M, Murai S and Morimatsu H (2019) Extracellular Glutamate Concentration Increases Linearly in Proportion to Decreases in Residual Cerebral Blood Flow After the Loss of Membrane Potential in a Rat Model of Ischemia, Journal of Neurosurgical Anesthesiology, 10.1097/ANA.0000000000000666, 33:4, (356-362), Online publication date: 1-Oct-2021. Cheung J, Doerr M, Hu R and Sun P (2020) Refined Ischemic Penumbra Imaging with Tissue pH and Diffusion Kurtosis Magnetic Resonance Imaging, Translational Stroke Research, 10.1007/s12975-020-00868-z, 12:5, (742-753), Online publication date: 1-Oct-2021. Berndt M, Goyal M, Psychogios M, Kaesmacher J, Boeckh-Behrens T, Wunderlich S, Zimmer C, Friedrich B and Maegerlein C (2020) Endovascular stroke treatment using balloon guide catheters may reduce penumbral tissue damage and improve long-term outcome, European Radiology, 10.1007/s00330-020-07260-3, 31:4, (2191-2198), Online publication date: 1-Apr-2021. Pires Monteiro S, Voogd E, Muzzi L, De Vecchis G, Mossink B, Levers M, Hassink G, Van Putten M, Le Feber J, Hofmeijer J and Frega M (2021) Neuroprotective effect of hypoxic preconditioning and neuronal activation in a in vitro human model of the ischemic penumbra, Journal of Neural Engineering, 10.1088/1741-2552/abe68a, 18:3, (036016), Online publication date: 1-Jun-2021. Mages B, Fuhs T, Aleithe S, Blietz A, Hobusch C, Härtig W, Schob S, Krueger M and Michalski D (2021) The Cytoskeletal Elements MAP2 and NF-L Show Substantial Alterations in Different Stroke Models While Elevated Serum Levels Highlight Especially MAP2 as a Sensitive Biomarker in Stroke Patients, Molecular Neurobiology, 10.1007/s12035-021-02372-3, 58:8, (4051-4069), Online publication date: 1-Aug-2021. Lu H, Meng Y, Han X, Zhang W and Jain D (2021) ADAM8 Activates NLRP3 Inflammasome to Promote Cerebral Ischemia-Reperfusion Injury, Journal of Healthcare Engineering, 10.1155/2021/3097432, 2021, (1-14), Online publication date: 16-Dec-2021. Ermine C, Bivard A, Parsons M and Baron J (2020) The ischemic penumbra: From concept to reality, International Journal of Stroke, 10.1177/1747493020975229, 16:5, (497-509), Online publication date: 1-Jul-2021. Zhang A, Song Y, Zhang Z, Jiang S, Chang S, Cai Z, Liu F, Zhang X and Ni G (2021) Effects of autophagy inhibitor 3-Methyladenine on ischemic stroke, Medicine, 10.1097/MD.0000000000023873, 100:4, (e23873) Zeng M, Shao C, Zhou H, He Y, Li W, Zeng J, Zhao X, Yang J and Wan H (2021) Protocatechudehyde improves mitochondrial energy metabolism through the HIF1α/PDK1 signaling pathway to mitigate ischemic stroke-elicited internal capsule injury, Journal of Ethnopharmacology, 10.1016/j.jep.2021.114232, 277, (114232), Online publication date: 1-Sep-2021. Lapa S, Wilmskötter J, Duchac S and Hofmayer A (2021) Dysphagie bei Schlaganfall FAQ Dysphagie, 10.1016/B978-3-437-44720-4.00006-6, (191-232), . Amki M and Wegener S (2021) Reperfusion failure despite recanalization in stroke: New translational evidence, Clinical and Translational Neuroscience, 10.1177/2514183X211007137, 5:1, (2514183X2110071), Online publication date: 1-Jan-2021. Schoknecht K, Kikhia M, Lemale C, Liotta A, Lublinsky S, Mueller S, Boehm-Sturm P, Friedman A and Dreier J (2020) The role of spreading depolarizations and electrographic seizures in early injury progression of the rat photothrombosis stroke model, Journal of Cerebral Blood Flow & Metabolism, 10.1177/0271678X20915801, 41:2, (413-430), Online publication date: 1-Feb-2021. Pulli B, Heit J and Wintermark M (2021) Computed Tomography–Based Imaging Algorithms for Patient Selection in Acute Ischemic Stroke, Neuroimaging Clinics of North America, 10.1016/j.nic.2020.12.002, 31:2, (235-250), Online publication date: 1-May-2021. Barthel H, Zeisig V, Nitzsche B, Patt M, Patt J, Becker G, Dreyer A, Boltze J and Sabri O (2021) Cerebral Blood Flow Measurement with Oxygen-15 Water Positron Emission Tomography PET and SPECT of Neurobiological Systems, 10.1007/978-3-030-53176-8_5, (127-152), . Ajčević M, Furlanis G, Miladinović A, Buoite Stella A, Caruso P, Ukmar M, Cova M, Naccarato M, Accardo A and Manganotti P (2021) Early EEG Alterations Correlate with CTP Hypoperfused Volumes and Neurological Deficit: A Wireless EEG Study in Hyper-Acute Ischemic Stroke, Annals of Biomedical Engineering, 10.1007/s10439-021-02735-w, 49:9, (2150-2158), Online publication date: 1-Sep-2021. Marshall H, Stewart N, Chan H, Rao M, Norquay G and Wild J (2021) In vivo methods and applications of xenon-129 magnetic resonance, Progress in Nuclear Magnetic Resonance Spectroscopy, 10.1016/j.pnmrs.2020.11.002, 122, (42-62), Online publication date: 1-Feb-2021. Sylvain N, Salman M, Pushie M, Hou H, Meher V, Herlo R, Peeling L and Kelly M (2021) The effects of trifluoperazine on brain edema, aquaporin-4 expression and metabolic markers during the acute phase of stroke using photothrombotic mouse model, Biochimica et Biophysica Acta (BBA) - Biomembranes, 10.1016/j.bbamem.2021.183573, 1863:5, (183573), Online publication date: 1-May-2021. Claassen J, Thijssen D, Panerai R and Faraci F (2021) Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation, Physiological Reviews, 10.1152/physrev.00022.2020, 101:4, (1487-1559), Online publication date: 1-Oct-2021. Beladi Moghadam N, Pourheidar E, Ahmadpour F, Kafi H, Salamzadeh J, Nasiri S and Sistanizad M (2021) The effects of memantine on the serum concentrations of matrix metalloproteinases and neurologic function of patients with ischemic stroke, Journal of Clinical Neuroscience, 10.1016/j.jocn.2021.06.005, 90, (268-272), Online publication date: 1-Aug-2021. Saber H and Liebeskind D (2021) Infarct Progression in the Early and Late Phases of Acute Ischemic Stroke, Neurology, 10.1212/WNL.0000000000012795, 97:20 Supplement 2, (S60-S67), Online publication date: 16-Nov-2021. Baron J (2021) The core/penumbra model: implications for acute stroke treatment and patient selection in 2021, European Journal of Neurology, 10.1111/ene.14916, 28:8, (2794-2803), Online publication date: 1-Aug-2021. Zheng Y, Zhou Z, Han F and Chen Z (2021) Autophagic regulation of neuroinflammation in ischemic stroke, Neurochemistry International, 10.1016/j.neuint.2021.105114, 148, (105114), Online publication date: 1-Sep-2021. Sueiras M, Thonon V, Santamarina E, Sánchez-Guerrero Á, Riveiro M, Poca M, Quintana M, Gándara D and Sahuquillo J (2020) Is Spreading Depolarization a Risk Factor for Late Epilepsy? A Prospective Study in Patients with Traumatic Brain Injury and Malignant Ischemic Stroke Undergoing Decompressive Craniectomy, Neurocritical Care, 10.1007/s12028-020-01107-x, 34:3, (876-888), Online publication date: 1-Jun-2021. Davis S and Donnan G (2021) Ischemic Penumbra: A Personal View, Cerebrovascular Diseases, 10.1159/000519730, 50:6, (656-665), . Yang S and Liu R (2021) Four Decades of Ischemic Penumbra and Its Implication for Ischemic Stroke, Translational Stroke Research, 10.1007/s12975-021-00916-2, 12:6, (937-945), Online publication date: 1-Dec-2021. Lin J, Hao C, Gong Y, Zhang Y, Li Y, Feng Z, Xu X, Huang H, Liao W and Zalewski P (2021) Effect of Tetramethylpyrazine on Neuroplasticity after Transient Focal Cerebral Ischemia Reperfusion in Rats, Evidence-Based Complementary and Alternative Medicine, 10.1155/2021/1587241, 2021, (1-10), Online publication date: 18-Jan-2021. Maglinger B, Sands M, Frank J, McLouth C, Trout A, Roberts J, Grupke S, Turchan-Cholewo J, Stowe A, Fraser J and Pennypacker K (2021) Intracranial VCAM1 at time of mechanical thrombectomy predicts ischemic stroke severity, Journal of Neuroinflammation, 10.1186/s12974-021-02157-4, 18:1, Online publication date: 1-Dec-2021. Krag A and Blauenfeldt R (2021) Fibrinolysis and Remote Ischemic Conditioning: Mechanisms and Treatment Perspectives in Stroke, Seminars in Thrombosis and Hemostasis, 10.1055/s-0041-1725095, 47:05, (610-620), Online publication date: 1-Jul-2021. (2021) References Child Neurology, 10.1016/B978-0-12-821635-4.00271-X, (1000-1023), . Xiang H, Zhang Q, Han Y, Yang L, Zhang Y, Liu Q, Zhang Z and Zhang L (2021) Novel brain-targeting 3-n-butylphthalide prodrugs for ischemic stroke treatment, Journal of Controlled Release, 10.1016/j.jconrel.2021.05.045, 335, (498-514), Online publication date: 1-Jul-2021. Wang C, Zhang X, Wu Y, Fu L and Fang Q (2021) Clinical Predictors for Functional Independence After Tissue-Window Guided Endovascular Thrombectomy, World Neurosurgery, 10.1016/j.wneu.2020.11.047, 146, (e947-e954), Online publication date: 1-Feb-2021. Scheuren P, David G, Kramer J, Jutzeler C, Hupp M, Freund P, Curt A, Hubli M and Rosner J (2021) Combined Neurophysiologic and Neuroimaging Approach to Reveal the Structure-Function Paradox in Cervical Myelopathy, Neurology, 10.1212/WNL.0000000000012643, 97:15, (e1512-e1522), Online publication date: 12-Oct-2021. Garcia-Esperon C, Raposo N, Seners P, Spratt N, Parsons M and Olivot J (2021) Role of neuroimaging before reperfusion therapy. Part 1 – IV thrombolysis – Review, Revue Neurologique, 10.1016/j.neurol.2020.10.007, 177:8, (908-918), Online publication date: 1-Oct-2021. Abu-samra M, Amin M, Yassen A, Fath El-Bab A and Gabr M (2021) SWI as a promising tool comparable to CT perfusion in evaluation of acute cerebral infarction, Egyptian Journal of Radiology and Nuclear Medicine, 10.1186/s43055-021-00629-4, 52:1, Online publication date: 1-Dec-2021. Xu Q, Zhao B, Ye Y, Li Y, Zhang Y, Xiong X and Gu L (2021) Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke, Journal of Neuroinflammation, 10.1186/s12974-021-02137-8, 18:1, Online publication date: 1-Dec-2021. Krusche C, Rio Bartulos C, Abu-Mugheisib M, Haimerl M, Wiggermann P, Küpper J, Krüger-Genge A and Jung F Dynamic perfusion analysis in acute ischemic stroke: A comparative study of two different softwares, Clinical Hemorheology and Microcirculation, 10.3233/CH-219106, 79:1, (55-63) Biscoito L (2021) Current Applications of Precision Medicine in Stroke: Acute Stroke Imaging Precision Medicine in Stroke, 10.1007/978-3-030-70761-3_6, (71-123), . Vupputuri A and Ghosh N (2021) Multi-view iterative random walker for automated salvageable tissue delineation in ischemic stroke from multi-sequence MRI, Journal of Neuroscience Methods, 10.1016/j.jneumeth.2021.109260, 360, (109260), Online publication date: 1-Aug-2021. Ross E (2021) Disorders of vocal emotional expression and comprehension: The aprosodias Disorders of Emotion in Neurologic Disease, 10.1016/B978-0-12-822290-4.00005-0, (63-98), . Ren Y, Jiang J, Jiang W, Zhou X, Lu W, Wang J and Luo Y (2021) Spata2 Knockdown Exacerbates Brain Inflammation via NF-κB/P38MAPK Signaling and NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Rats, Neurochemical Research, 10.1007/s11064-021-03360-8, 46:9, (2262-2275), Online publication date: 1-Sep-2021. Caplan L (2020) Journal Stroke, Stroke, 51:3, (1025-1026), Online publication date: 1-Mar-2020.Demeestere J, Wouters A, Christensen S, Lemmens R and Lansberg M (2020) Review of Perfusion Imaging in Acute Ischemic Stroke, Stroke, 51:3, (1017-1024), Online publication date: 1-Mar-2020.Kwak H and Park J (2020) Mechanical Thrombectomy in Basilar Artery Occlusion, Stroke, 51:7, (2045-2050), Online publication date: 1-Jul-2020.Davis S, Hacke W, Norrving B, Brainin M, Lees K and Donnan G (2020) International Impact of Stroke, Stroke, 51:3, (1036-1039), Online publication date: 1-Mar-2020.Li Z, Lindner D, Bishop N and Cipolla M (2020) ACE (Angiotensin-Converting Enzyme) Inhibition Reverses Vasoconstriction and Impaired Dilation of Pial Collaterals in Chronic Hypertension, Hypertension, 76:1, (226-235), Online publication date: 1-Jul-2020. Cho S, Kim J and Cho N (2020) The Effect of Intra-arterial Thrombolysis in Retinal Artery Occlusion: Case Series and Literature Review, Journal of the Korean Ophthalmological Society, 10.3341/jkos.2020.61.12.1442, 61:12, (1442-1449), Online publication date: 15-Dec-2020. Hwang G and Shin Y (2020) Protective Effects of Chongmyunggongjin-dan on H2O2-induced C6 Glial Cell Death, The Journal of Internal Korean Medicine, 10.22246/jikm.2020.41.1.44, 41:1, (44-58), Online publication date: 31-Mar-2020. Campbell B and Khatri P (2020) Stroke, The Lancet, 10.1016/S0140-6736(20)31179-X, 396:10244, (129-142), Online publication date: 1-Jul-2020. Mnatsakanyan N and Jonas E (2020) The new role of F1Fo ATP synthase in mitochondria-mediated neurodegeneration and neuroprotection, Experimental Neurology, 10.1016/j.expneurol.2020.113400, 332, (113400), Online publication date: 1-Oct-2020. Kangussu L, Marzano L, Souza C, Dantas C, Miranda A and Simões e Silva A The Renin-Angiotensin System and the Cerebrovascular Diseases: Experimental and Clinical Evidence, Protein & Peptide Letters, 10.2174/0929866527666191218091823, 27:6, (463-475) Malcharek M, Schneider G and Dinkel M (2020) Carotid endarterectomy Neurophysiology in Neurosurgery, 10.1016/B978-0-12-815000-9.00025-3, (335-350), . Lee J, Hong J, Yoon B, Son K, Lee K, Im D, Park B, An Y, Hwang D, Park C, Kim B and Joe E (2020) Expression of Cellular Receptors in the Ischemic Hemisphere of Mice with Increased Glucose Uptake, Experimental Neurobiology, 10.5607/en.2020.29.1.70, 29:1, (70-79), Online publication date: 29-Feb-2020. Ironside N, Christophe B, Bruce S, Carpenter A, Robison T, Yoh N, Cremers S, Landry D, Frey H, Chen C, Hoh B, Kim L, Claassen J and Connolly E A phase II randomized controlled trial of tiopronin for aneurysmal subarachnoid hemorrhage, Journal of Neurosurgery, 10.3171/2019.4.JNS19478, 133:2, (351-359) Zu Z, Vandsburger M and Sun P (2020) Chemical Exchange Mapping Quantitative Magnetic Resonance Imaging, 10.1016/B978-0-12-817057-1.00034-2, (857-883), . Figaji A (2020) Physiological Responses of the Newborn, Infant, and Child to Neurosurgical Trauma Textbook of Pediatric Neurosurgery, 10.1007/978-3-319-72168-2_4, (133-151), . Mizutani K (2020) Neuro-vascular Interactions during Neocortical Development—Systematic and Accurate Regulatory Mechanisms of VEGF Signaling—大脳皮質における血管・神経の協調的な発生制御機構~VEGFシグナルの緻密な調節~, YAKUGAKU ZASSHI, 10.1248/yakushi.19-00221-3, 140:4, (521-527), Online publication date: 1-Apr-2020. Amukotuwa S, Bell L and Thomas D (2020) Applications of Quantitative Perfusion and Permeability in the Brain Quantitative Magnetic Resonance Imaging, 10.1016/B978-0-12-817057-1.00017-2, (369-403), . Valent A, Chousterman B and Gayat E (2020) Spécificités de la prise en charge anesthésique de la thrombectomie mécanique dans l’accident vasculaire cérébral ischémique, Anesthésie & Réanimation, 10.1016/j.anrea.2019.11.006, 6:1, (28-38), Online publication date: 1-Jan-2020. Liu J, Wang T, Lin Y, Ho W, Tsai H, Chen S, Lin A, Liu T and Wang H (2020) Acrolein is involved in ischemic stroke-induced neurotoxicity through spermidine/spermine-N1-acetyltransferase activation, Experimental Neurology, 10.1016/j.expneurol.2019.113066, 323, (113066), Online publication date: 1-Jan-2020. Liu X, Wang Q, Cui Y, Hussain M, Yang H and Li X (2020) Multiple protein and mRNA expression correlations in the rat cerebral cortex after ischemic injury and repair due to buchang naoxintong jiaonang (BNJ) intervention, Biomedicine & Pharmacotherapy, 10.1016/j.biopha.2020.109917, 125, (109917), Online publication date: 1-May-2020. Kaiser E and West F (2020) Large animal ischemic stroke models: replicating human stroke pathophysiology, Neural Regeneration Research, 10.4103/1673-5374.274324, 15:8, (1377), . Iadecola C, Buckwalter M and Anrather J (2020) Immune responses to stroke: mechanisms, modulation, and therapeutic potential, Journal of Clinical Investigation, 10.1172/JCI135530, 130:6, (2777-2788), Online publication date: 11-May-2020., Online publication date: 1-Jun-2020. Aracki-Trenkic A, Law-ye B, Radovanovic Z, Stojanov D, Dormont D and Pyatigorskaya N (2020) ASL perfusion in acute ischemic stroke: The value of CBF in outcome prediction, Clinical Neurology and Neurosurgery, 10.1016/j.clineuro.2020.105908, 194, (105908), Online publication date: 1-Jul-2020. He Z, Ning N, Zhou Q, Khoshnam S and Farzaneh M (2020) Mitochondria as a therapeutic target for ischemic stroke, Free Radical Biology and Medicine, 10.1016/j.freeradbiomed.2019.11.005, 146, (45-58), Online publication date: 1-Jan-2020. Hartings J, Andaluz N, Bullock M, Hinzman J, Mathern B, Pahl C, Puccio A, Shutter L, Strong A, Vagal A, Wilson J, Dreier J, Ngwenya L, Foreman B, Pahren L, Lingsma H and Okonkwo D (2020) Prognostic Value of Spreading Depolarizations in Patients With Severe Traumatic Brain Injury, JAMA Neurology, 10.1001/jamaneurol.2019.4476, 77:4, (489), Online publication date: 1-Apr-2020. Choi S and Kim J (2020) Recent Progress in Autocatalytic Ceria Nanoparticles-Based Translational Research on Brain Diseases, ACS Applied Nano Materials, 10.1021/acsanm.9b02243, 3:2, (1043-1062), Online publication date: 28-Feb-2020. Jha M, Mishra H, Chaudhary A and Jana D (2020) ANALYSIS OF HEMATOLOGICAL PARAMETERS IN PATIENTS WITH ISCHEMIC STROKE AT DMCH, LAHERIASARAI, BIHAR, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, 10.36106/ijsr/3226133, (49-51), Online publication date: 1-Nov-2020. Koepsell H (2020) Glucose transporters in brain in health and disease, Pflügers Archiv - European Journal of Physiology, 10.1007/s00424-020-02441-x, 472:9, (1299-1343), Online publication date: 1-Sep-2020. Matei N, Leahy S, Auvazian S, Thomas B, Blair N and Shahidi M (2020) Relation of Retinal Oxygen Measures to Electrophysiology and Survival Indicators after Permanent, Incomplete Ischemia in Rats, Translational Stroke Research, 10.1007/s12975-020-00799-9, 11:6, (1273-1286), Online publication date: 1-Dec-2020. Shimura S, Odagiri S, Furuya H, Okada K, Ozawa K, Nagase H, Yamaguchi M and Cho Y (2020) Echocardiography-guided aortic cannulation by the Seldinger technique for type A dissection with cerebral malperfusion, The Journal of Thoracic and Cardiovascular Surgery, 10.1016/j.jtcvs.2019.02.097, 159:3, (784-793), Online publication date: 1-Mar-2020. Zhao W, Wu C, Dornbos III D, Li S, Song H, Wang Y, Ding Y and Ji X (2020) Multiphase adjuvant neuroprotection: A novel paradigm for improving acute ischemic stroke outcomes, Brain Circulation, 10.4103/bc.bc_58_19, 6:1, (11), . Baron J, Markus H, Pickard J, Davis S and Donnan G (2020) Lindsay Symon: A giant of stroke, International Journal of Stroke, 10.1177/1747493020913088, 15:4, (356-360), Online publication date: 1-Jun-2020. Merenda A, De Georgia M and Hemphill J (2020) Intracranial Pressure and Multimodal Monitoring Neurocritical Care Informatics, 10.1007/978-3-662-59307-3_4, (43-77), . Rasouli B, Ghahari L, Safari M, Shahroozian E and Naeimi S (2020) Combination therapy of the granulocyte colony stimulating factor and intravenous lipid emulsion protect the hippocampus after global ischemia in rat: focusing on CA1 region, Metabolic Brain Disease, 10.1007/s11011-020-00579-2, 35:6, (991-997), Online publication date: 1-Aug-2020. Gaines N and Liebeskind D (2020) Brain Hemodynamics Stroke Revisited: Pathophysiology of Stroke, 10.1007/978-981-10-1430-7_15, (215-232), . Sodaei F and Shahmaei V (2020) Identification of penumbra in acute ischemic stroke using multimodal MR imaging analysis: A case report study, Radiology Case Reports, 10.1016/j.radcr.2020.07.066, 15:10, (2041-2046), Online publication date: 1-Oct-2020. He J, Rabiller G, Nishijima Y, Akamatsu Y, Khateeb K, Yazdan-Shahmorad A and Liu J (2019) Experimental cortical stroke induces aberrant increase of sharp-wave-associated ripples in the hippocampus and disru