磷酸八钙
结晶
化学工程
热液循环
布洛芬
材料科学
水热合成
吸附
微晶
磷酸盐
核化学
化学
有机化学
药理学
医学
工程类
冶金
作者
Chengfeng Li,Xiaolu Ge,Guochang Li,Qiao-Chun Gao,Rui Ding
标识
DOI:10.1016/j.apt.2014.06.001
摘要
A facile hydrothermal method was employed to synthesize submillimeter-long octacalcium phosphate (OCP) and hydroxyapatite (HAp) crystals as drug carriers. After hydrolysis reaction of urea, calcium phosphate fibers grew preferentially along c-axis due to modulation of crystallization by glutamic acid. With increasing addition of urea, OCP and HAp precipitated with decreased values of crystallite size and aspect ratio. It was found that the conversion of OCP to HAp was completed after hydrothermal treatment at 160 °C for 6 h. The formation of fibrous crystals and adsorption of water-insoluble drugs were accomplished in one-step synthesis process with presence of ibuprofen molecules. The sustained-release behavior of ibuprofen could be described by a Higuchi model. HAp and OCP fibers might be simultaneously used for high-performance reinforcements to improve mechanical properties of composite materials and sustained-release drug carriers to cure postoperative infection of bone replacement.
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