281 Angiotensin converting enzyme 2 (ACE2)deficiency results in endothelial dysfunction and worsens diabetic cardiomyopathy

Incidence of heart disease and severity of heart failure is high in diabetic, than the non-diabetic. This increased risk appears to be due to hyperglycemia stimulated cardiac angiotensin II formation, which has been implicated in increased cardiac dysfunction. Angiotensin converting enzyme 2 (ACE2) is a homolog of the ACE that breaks down Ang II to Ang 1-7, that has the capacity to counter the actions of Ang II.