钙黄绿素
中间神经元
加巴能
神经科学
生物
生长抑素
神经节隆起
帕尔瓦布明
皮质(解剖学)
抑制性突触后电位
免疫组织化学
免疫学
作者
Daichi Tanaka,Shuji Mikami,Takashi Nagasawa,Jun‐ichi Miyazaki,Kazunori Nakajima,Fujio Murakami
出处
期刊:Cerebral Cortex
[Oxford University Press]
日期:2010-03-03
卷期号:20 (12): 2810-2817
被引量:37
标识
DOI:10.1093/cercor/bhq027
摘要
Cortical GABAergic interneurons are divided into various subtypes, with each subtype contributing to rich variety and fine details of inhibition. Despite the functional importance of each interneuron subtype, the molecular mechanisms that contribute to sorting them to their appropriate positions within the cortex remain unclear. Here, we show that the chemokine receptor CXCR4 regulates the regional and layer-specific distribution of interneuron subtypes. We removed Cxcr4 specifically in a subset of interneurons at a specific mouse embryonic developmental stage and analyzed the number of interneurons and their laminar distribution in 9 representative cortical regions comprehensively in adults. We found that the number of Cxcr4-deleted calretinin- and that of neuropeptide Y-expressing interneurons were reduced in most caudomedial and lateral cortical regions, respectively, and also in superficial layers. In addition, Cxcr4-deleted somatostatin-expressing interneurons showed a reduction in the number of superficial layers in certain cortical regions but of deep layers in others. These findings suggest that CXCR4 is required for proper regional and laminar distribution in a wider interneuron subpopulation than previously thought and may regulate the establishment of functional cortical circuitry in certain cortical regions and layers.
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