Preparation and Evaluation of Molecular Imprinted Polymers of Erythromycin

Molecular imprinted polymers were synthesized with precipitation polymerization in the present study when Erythromycin was used as template, methacrylic acid as functional monomer, and ethylene glycol dimethacrylate as cross-linker. The best synthesis solution was ultimately determined when the bonding property of the polymer was studied. The selectivity of imprinted polymer on Erythromycin was also studied. The equilibrium binding experiments showed that the binding site of MIPs was heterogeneous with one binding site. Equilibrium dissociation constant was 0.663mg/ml, maximum apparent adsorption was 91.39mg/g.