生物
互补DNA
同源染色体
分子生物学
酵母
激活剂(遗传学)
分离(微生物学)
遗传学
基因
生物信息学
作者
M. lnoue,Minoru Isomura,Shiro lkegawa,T Fujiwara,Sang Mi Shin,Hidekazu Moriya,Yoshimasa Nakamura
摘要
We have isolated a novel human cDNA with a predicted amino acid sequence homologous to GCN5, a protein considered to be a regulator of transcriptional activation in yeast. This cDNA, termed GCN5L1 (GCN5-like 1), consists of 545 nucleotides including an open reading frame of 378 bp that encodes a 126-amino-acid peptide having 23.5% identity to yeast GCN5. Northern-blot analysis revealed transcription of this gene in all human tissues examined. We isolated a genomic clone corresponding to this cDNA from a human cosmid library and mapped it to chromosome 12q13→q14 by fluorescent in situ hybridization (FISH).
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