纳米生物技术
纳米医学
胶体金
生物物理学
纳米技术
胞饮病
纳米颗粒
细胞毒性
化学
内吞作用
内化
共焦显微镜
促炎细胞因子
细胞生物学
材料科学
纳米毒理学
生物相容性
细胞
体外
生物
炎症
生物化学
免疫学
有机化学
作者
Ravi Shukla,Vipul Bansal,Minakshi Chaudhary,Atanu Basu,Ramesh Bhonde,Murali Sastry
出处
期刊:Langmuir
[American Chemical Society]
日期:2005-09-27
卷期号:21 (23): 10644-10654
被引量:1602
摘要
Macrophages are one of the principal immune effector cells that play essential roles as secretory, phagocytic, and antigen-presenting cells in the immune system. In this study, we address the issue of cytotoxicity and immunogenic effects of gold nanoparticles on RAW264.7 macrophage cells. The cytotoxicity of gold nanoparticles has been correlated with a detailed study of their endocytotic uptake using various microscopy tools such as atomic force microscopy (AFM), confocal-laser-scanning microscopy (CFLSM), and transmission electron microscopy (TEM). Our findings suggest that Au(0) nanoparticles are not cytotoxic, reduce the production of reactive oxygen and nitrite species, and do not elicit secretion of proinflammatory cytokines TNF-α and IL1-β, making them suitable candidates for nanomedicine. AFM measurements suggest that gold nanoparticles are internalized inside the cell via a mechanism involving pinocytosis, while CFLSM and TEM studies indicate their internalization in lysosomal bodies arranged in perinuclear fashion. Our studies thus underline the noncytotoxic, nonimmunogenic, and biocompatible properties of gold nanoparticles with the potential for application in nanoimmunology, nanomedicine, and nanobiotechnology.
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