MAPK/ERK通路
磷酸酶
先天免疫系统
免疫系统
细胞生物学
蛋白激酶A
功能(生物学)
生物
蛋白磷酸酶2
激酶
DUSP6型
磷酸化
丝裂原活化蛋白激酶
免疫学
作者
Liu Y,Edward G. Shepherd,Leif D. Nelin
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2007-02-23
卷期号:7 (3): 202-212
被引量:639
摘要
Mitogen-activated protein kinase (MAPK) phosphatases (MKPs) are protein phosphatases that dephosphorylate both the phosphothreonine and phosphotyrosine residues on activated MAPKs. Removal of the phosphates renders MAPKs inactive, effectively halting their cellular function. In recent years, evidence has emerged that, similar to MAPKs, MKPs are pivotal in the regulation of immune responses. By deactivating MAPKs, MKPs can modulate both innate and adaptive immunity. A number of immunomodulatory agents have been found to influence the expression of MKP1 in particular, highlighting the central role of this phosphatase in immune regulation. This Review discusses the properties, function and regulation of MKPs during immune responses.
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