成纤维细胞生长因子
血管生成
细胞生物学
碱性成纤维细胞生长因子
细胞外基质
运动性
生物
分泌物
成纤维细胞
细胞生长
生长因子
生物活性
体内
细胞培养
内分泌学
癌症研究
体外
生物化学
受体
遗传学
出处
期刊:Progress in Growth Factor Research
[Elsevier]
日期:1989-01-01
卷期号:1 (4): 207-235
被引量:348
标识
DOI:10.1016/0955-2235(89)90012-4
摘要
This article summarizes the structural and biological properties of the family of fibroblast growth factors (FGF). Basic FGF (bFGF) and acidic FGF (aFGF) are the best characterized members of this family. bFGF and aFGF are potent modulators of cell proliferation, motility and differentiation. They are also potent angiogenesis factors in vivo. Some of the important biological characteristics of bFGF and aFGF discussed in the review include the affinity of bFGF and aFGF for heparin, their lack of secretion in culture and their association with extracellular matrix. Recently, several oncogenes, 40-50% homologous in sequence to bFGF and aFGF have been identified. These include int-2, hst, K-fgf and FGF-5. The structural and biological properties of these FGF-related oncogenes are also discussed.
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