自愈水凝胶
药物输送
计算机科学
药品
建模与仿真
联轴节(管道)
化学
生化工程
药理学
材料科学
生物系统
纳米技术
模拟
工程类
医学
有机化学
冶金
生物
作者
Diego Caccavo,Sara Cascone,Gaetano Lamberti,Anna Angela Barba,Anette Larsson
出处
期刊:Current Drug Delivery
[Bentham Science]
日期:2016-08-08
卷期号:13 (999): 1-1
被引量:7
标识
DOI:10.2174/1567201813666160808102106
摘要
The controlled delivery of drugs, including siRNAs, can be effectively obtained using Hydrogel- Based Drugs Delivery Systems (HB-DDSs). Successful design of HB-DDSs requires the knowledge of the mechanisms that influence drug release. The modeling of the physical phenomena involved could help in the development and optimization of HB-DDS, sensibly reducing the time and costs required by a trial-and-error procedures. The modeling is rather complex because of the presence of several, synergistic and competing, transport phenomena. In this work a general framework useful for modeling the HB-DDS has been derived and it is proposed, coupling and homogenizing the literature models. It is shown that all of them can be traced back to two different approaches: multiphasic models and multicomponent mixture models. In the first one the hydrogel is seen as constituted by different phases, the behavior of each one being described by their own mass and momentum conservation equations. In the second approach, the hydrogel is considered as made of one phase composed by several components. Keywords: Controlled drug delivery, hydrogels, mathematical modeling, siRNAs.
科研通智能强力驱动
Strongly Powered by AbleSci AI