细胞凋亡
癌细胞
癌症
程序性细胞死亡
癌症研究
生物
细胞生物学
过程(计算)
遗传学
计算机科学
操作系统
作者
Gabriel Ichim,Stephen W.G. Tait
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2016-07-01
卷期号:16 (8): 539-548
被引量:330
摘要
Apoptotic cell death undoubtedly has beneficial roles in cancer, but paradoxically, apoptosis can also cause unwanted effects that could promote cancer. This Opinion article highlights some of the ways in which apoptosis can exert oncogenic functions. Apoptotic cell death is widely considered a positive process that both prevents and treats cancer. Although undoubtedly having a beneficial role, paradoxically, apoptosis can also cause unwanted effects that may even promote cancer. In this Opinion article we highlight some of the ways by which apoptosis can exert oncogenic functions. We argue that fully understanding this dark side will be required to optimally engage apoptosis, thereby maximizing tumour cell kill while minimizing unwanted pro-tumorigenic effects.
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