L-carnitine treatment of insulin resistance: A systematic review and meta-analysis

医学 内科学 肉碱 胰岛素抵抗 科克伦图书馆 随机对照试验 养生 纳入和排除标准 胃肠病学 荟萃分析 体质指数 胰岛素 病理 替代医学
作者
Ying Xu,Wenjie Jiang,Guochang Chen,Wenjiao Zhu,Weiliang Ding,Zhijun Ge,Yongfei Tan,Tieliang Ma,Cui Guo-xing
出处
期刊:Advances in Clinical and Experimental Medicine [Wroclaw Medical University]
卷期号:26 (2): 333-338 被引量:84
标识
DOI:10.17219/acem/61609
摘要

Background. L-carnitine has been used for several years as an adjuvant therapy in oxidative stress, blood sugar, high-sensitivity C-reactive protein (CRP), anemia, etc. However, the efficacy of L-carnitine treating insulin resistance (IR) remains controversial. Homeostasis model assessment of Insulin Resistance (HOMA-IR) is widely used in the clinical evaluation of patients with IR.Objectives. A meta-analysis, including randomized controlled trials (RCTs), was performed to assess the effect of L-carnitine on HOMA-IR patients.Material and Methods. The Cochrane Library, PubMed, and EMBASE databases were systematically searched to identify RCTs which evaluated the effects of L-carnitine on HOMA-IR patients. We screened relevant studies according to predefined inclusion and exclusion criteria. In the selected articles, we extracted the data: study design, sample size, age, L-carnitine dose and regimen, body mass index (BMI) of patients, mode of administration, study duration and study outcomes.Results. A total of 5 studies were included for the meta-analysis. The result showed L-carnitine was useful in the treatment of IR (WMD –0.724, CI –0.959 –0.488, p < 0.0001). Evaluation at 3, 6, 9, 12 months, the p-values were 0.875, 0.165, 0.031, 0, 007, respectively.Conclusion. L-carnitine was useful in treating patients with IR. L-carnitine can treat IR more effectively with prolonging the medication time. However, more RCTs with long-term L-carnitine treatment of IR are needed to confirm the viewpoint.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
伯赏人杰完成签到,获得积分10
刚刚
俏皮诺言发布了新的文献求助10
1秒前
1秒前
2秒前
3秒前
yxyer发布了新的文献求助10
4秒前
张爱学发布了新的文献求助10
5秒前
5秒前
九耳久知发布了新的文献求助10
5秒前
溫蒂完成签到,获得积分10
6秒前
6秒前
8R60d8应助QQ采纳,获得10
7秒前
lwh104完成签到,获得积分10
7秒前
LZHWSND发布了新的文献求助10
7秒前
俏皮秋双发布了新的文献求助10
8秒前
YisShy完成签到,获得积分10
8秒前
8秒前
9秒前
11秒前
xinyue发布了新的文献求助10
11秒前
13秒前
14秒前
喜悦的丝发布了新的文献求助10
14秒前
俏皮秋双完成签到,获得积分20
14秒前
14秒前
妙质完成签到,获得积分20
15秒前
melon应助YisShy采纳,获得10
16秒前
lithion发布了新的文献求助10
16秒前
慕青应助流浪采纳,获得10
16秒前
aaa发布了新的文献求助10
17秒前
18秒前
爱静静应助冷酷含羞草采纳,获得10
19秒前
20秒前
zz完成签到,获得积分10
20秒前
AM应助淡淡铃铛采纳,获得10
20秒前
21秒前
小新完成签到 ,获得积分10
21秒前
dahafei发布了新的文献求助30
21秒前
sdgsdh发布了新的文献求助10
23秒前
壮观晓兰发布了新的文献求助10
24秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Semiconductor Process Reliability in Practice 1500
Handbook of Prejudice, Stereotyping, and Discrimination (3rd Ed. 2024) 1200
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 1000
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3243918
求助须知:如何正确求助?哪些是违规求助? 2887807
关于积分的说明 8249895
捐赠科研通 2556414
什么是DOI,文献DOI怎么找? 1384557
科研通“疑难数据库(出版商)”最低求助积分说明 649901
邀请新用户注册赠送积分活动 625867