Self-propelled Au-BP7@SP Janus-like nanohybrids with active motion under NIR laser can effectively enhance the temperature of tumors, potentially by converting the kinetic energy into thermal energy, enhancing photothermal tumor therapy. On page 5423, Y.-S. Li, L. Wang, H. Wang, and co-workers provide an insight into nanohybrids' effect on photothermal treatment and open a new avenue to cancer treatment by using self-propulsion Janus nanohybrids.