化学
钋
表面改性
分子
组合化学
有机化学
序列(生物学)
生物化学
物理化学
作者
Michael C. Hilton,Ryan D. Dolewski,Andrew McNally
摘要
Methods that directly functionalize pyridines are in high demand due to their presence in pharmaceuticals, agrochemicals, and materials. A reaction that selectively transforms the 4-position C-H bonds in pyridines into C-PPh3+ groups that are subsequently converted into heteroaryl ethers is presented. The two step sequence is effective on complex pyridines, pharmaceutical molecules, and other classes of heterocycles. Initial studies show that C-C, C-N, and C-S bond formations are also amenable.
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