[Community-acquired methicillin-resistant Staphylococcus aureus infections in children: multicenter trial].

医学 克林霉素 金黄色葡萄球菌 菌血症 肺炎 耐甲氧西林金黄色葡萄球菌 内科学 抗生素 脓胸 骨髓炎 败血症 儿科 外科 微生物学 遗传学 细菌 生物
作者
Hugo Paganini,María Paula Della Latta,Beatriz Muller Opet,Gustavo Ezcurra,Macarena Uranga,Clarisa Aguirre,Gabriela Ensinck,Marys Kamiya de Macarrein,María R. Miranda,Cristina Ciriaci,Claudia Hernández,Lidia Casimir,María José Rial,Norma Schenonne,Estela Ronchi,María del Carmen Navarro Rodríguez,Fabiana Aprile,C. Ricco,Viviana García Saito,Claudia Vrátnica,Laura Peydró Pons,Adriana Ernst,Sandra Morinigo,Marcelo Toffoli,Celia Bosque,Victoria Monzani,Andrea Lo Monaco,José Luís Palmeiro Pinheiro,María del Pilar Abollo López,Leonardo Maninno,Claudia Sarkis
出处
期刊:PubMed 卷期号:106 (5): 397-403 被引量:52
标识
DOI:10.1590/s0325-00752008000500005
摘要

Methicillin-resistant Staphylococcus aureus (MRSA) isolates are increasingly frequent causes of skin and soft-tissue infections or invasive infections in many communities. Local data are scarce.To determine the frequency, clinical features and outcome of infections caused by MRSA.Prospective and multicentric study of surveillance for community-acquired S. aureus infections in children from Argentina. Infections meeting the definition of community-acquired were identified. Demographic and clinical data were collected. Antibiotic susceptibilities were determined in the clinical microbiology laboratory with the methodology of the NCCLS.From November 2006 to November 2007, 840 S. aureus infections were diagnosed, 447 of them were community-acquired. One hundred and thirty-five children with underlying disease or previous hospital admission were excluded. Two hundred and eighty one (62%) infections were community-acquired MRSA (CA-MRSA). The median age of children was 36 months (r:1-201), 60% were male. Among the CA-MRSA isolates, 62% were obtained from children with skin and soft-tissue infections, and 38% from children with invasive infections. Of them, osteomyelitis, arthritis, empyema and pneumonia were prevalent. Eigthteen percent of children had bacteremia and 11% sepsis. The rate of clindamycin resistance of CA-MRSA isolates was 10% and 1% for trimethoprim-sulfamethoxazole. Only 31% of children had appropriate treatment at admission. The median time of treatment delayed was 72 h. The median time of parenteral treatment was 6 days (r:1-70). In 72% of patients surgical treatment was required. Three children died (1%).CA-MRSA isolates account for a high percentage and number of infections in children of Argentina. Community surveillance of CA-MRSA infections is critical to determine the appropriate empiric antibiotic treatment for either local or invasive infections. Clindamycin resistance was under 15% in the strains tested. Clindamycin should be use when CA-MRSA infection is suspected in children.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
吴wu完成签到 ,获得积分20
1秒前
干秋白完成签到,获得积分10
3秒前
3秒前
3秒前
应俊完成签到 ,获得积分10
4秒前
4秒前
潘婷婷呀完成签到,获得积分10
5秒前
haha完成签到,获得积分10
5秒前
Georges-09完成签到,获得积分10
6秒前
6秒前
zzzzz完成签到,获得积分10
6秒前
8秒前
8秒前
赵维雪发布了新的文献求助10
8秒前
9秒前
9秒前
agent完成签到 ,获得积分10
9秒前
9秒前
GK发布了新的文献求助10
10秒前
10秒前
xhnmdl完成签到 ,获得积分10
10秒前
华仔应助LL采纳,获得10
11秒前
就叫希望吧完成签到 ,获得积分10
12秒前
小眼儿发布了新的文献求助10
12秒前
13秒前
江幻天发布了新的文献求助10
13秒前
医文轩完成签到,获得积分10
13秒前
田様应助赵维雪采纳,获得10
14秒前
冷静完成签到,获得积分20
14秒前
14秒前
琉尔发布了新的文献求助10
15秒前
乐乐了完成签到,获得积分10
15秒前
烟花应助pingping采纳,获得30
15秒前
仇夜羽完成签到 ,获得积分10
15秒前
matchais1ife完成签到 ,获得积分10
15秒前
Zooey旎旎完成签到,获得积分10
15秒前
搞科研的静静完成签到,获得积分10
16秒前
16秒前
花花发布了新的文献求助10
16秒前
16秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Very-high-order BVD Schemes Using β-variable THINC Method 850
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3249184
求助须知:如何正确求助?哪些是违规求助? 2892574
关于积分的说明 8272367
捐赠科研通 2560837
什么是DOI,文献DOI怎么找? 1389258
科研通“疑难数据库(出版商)”最低求助积分说明 651066
邀请新用户注册赠送积分活动 627936