Shared and distinct mechanisms of fibrosis

医学 纤维化 疾病 药物开发 Wnt信号通路 刺猬 生物信息学 生长因子 转化生长因子 机制(生物学) 癌症研究 病理 信号转导 药品 生物 受体 药理学 内科学 认识论 哲学 生物化学
作者
Jörg H. W. Distler,Andrea‐Hermina Györfi,Meera Ramanujam,Michael L. Whitfield,Mélanie Königshoff,Robert Lafyatis
出处
期刊:Nature Reviews Rheumatology [Nature Portfolio]
卷期号:15 (12): 705-730 被引量:439
标识
DOI:10.1038/s41584-019-0322-7
摘要

Fibrosis is defined as an excessive deposition of connective tissue components and can affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue remodelling often leads to organ malfunction and is commonly associated with high morbidity and mortality. The medical need for effective antifibrotic therapies is thus very high. However, the extraordinarily high costs of drug development and the rare incidence of many fibrotic disorders hinder the development of targeted therapies for individual fibrotic diseases. A potential strategy to overcome this challenge is to target common mechanisms and core pathways that are of central pathophysiological relevance across different fibrotic diseases. The factors influencing susceptibility to and initiation of these diseases are often distinct, with disease-specific and organ-specific risk factors, triggers and sites of first injury. Fibrotic remodelling programmes with shared fibrotic signalling responses such as transforming growth factor-β (TGFβ), platelet-derived growth factor (PDGF), WNT and hedgehog signalling drive disease progression in later stages of fibrotic diseases. The convergence towards shared responses has consequences for drug development as it might enable the development of general antifibrotic compounds that are effective across different disease entities and organs. Technological advances, including new models, single-cell technologies and gene editing, could provide new insights into the pathogenesis of fibrotic diseases and the development of drugs for their treatment. A number of core pathways and mechanisms of fibrosis, outlined in this Review, are shared across different tissues and might therefore present targets for general antifibrotic strategies. Organ-specific and disease-specific differences in fibrotic diseases could also provide insights for drug development efforts.
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