泡沫电池
炎症
疾病
医学
脂质代谢
免疫系统
心肌梗塞
动脉壁
病态的
冲程(发动机)
病变
发病机制
脂蛋白
生物信息学
神经科学
免疫学
病理
心脏病学
生物
内科学
胆固醇
工程类
机械工程
作者
Anastasia V. Poznyak,Wei‐Kai Wu,Alexandra А. Melnichenko,Reinhard Wetzker,Vasily N. Sukhorukov,Alexander M. Markin,Victoria A. Khotina,Alexander N. Orekhov
出处
期刊:Cells
[MDPI AG]
日期:2020-03-01
卷期号:9 (3): 584-584
被引量:67
摘要
Atherosclerosis is associated with acute cardiovascular conditions, such as ischemic heart disease, myocardial infarction, and stroke, and is the leading cause of morbidity and mortality worldwide. Our understanding of atherosclerosis and the processes triggering its initiation is constantly improving, and, during the last few decades, many pathological processes related to this disease have been investigated in detail. For example, atherosclerosis has been considered to be a chronic inflammation triggered by the injury of the arterial wall. However, recent works showed that atherogenesis is a more complex process involving not only the immune system, but also resident cells of the vessel wall, genetic factors, altered hemodynamics, and changes in lipid metabolism. In this review, we focus on foam cells that are crucial for atherosclerosis lesion formation. It has been demonstrated that the formation of foam cells is induced by modified low-density lipoprotein (LDL). The beneficial effects of the majority of therapeutic strategies with generalized action, such as the use of anti-inflammatory drugs or antioxidants, were not confirmed by clinical studies. However, the experimental therapies targeting certain stages of atherosclerosis, among which are lipid accumulation, were shown to be more effective. This emphasizes the relevance of future detailed investigation of atherogenesis and the importance of new therapies development.
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