The relationship between chronic stress and tumor

The relationship between chronic stress caused by fast-paced lifestyle and tumor has been widely concerned. A large number of epidemiological and clinical studies have found that long-term depression, anxiety, depression and chronic stress state, such as social isolation can significantly affect the neuroendocrine system, immune system and the composition and function of the gut microbiota, then produce inflammation as well as a variety of antitumor drug resistance, which are closely related to the proliferation, metastasis and treatment of tumor. Effective stress management and personalized approaches to cancer prevention and treatment are critical. In this review, the effects and mechanisms of chronic stress on tumors are summarized as follows. Key words: Chronic stress; Neuroendocrine system; Immune system; Gut microbiota; Antitumor drug resistance; Tumor