抗菌剂
自愈水凝胶
微生物学
淀粉
青霉素
化学
金黄色葡萄球菌
化脓性链球菌
大肠杆菌
药物输送
抗生素
细菌
食品科学
生物化学
生物
有机化学
基因
遗传学
作者
Suk Fun Chin,Ain Nadirah Binti Romainor,Suh Cem Pang,Samuel Lihan
标识
DOI:10.1016/j.jddst.2019.101239
摘要
Antimicrobial starch-citrate hydrogels were prepared by physical crosslinking of starch citrate, Poly(vinyl alcohol (PVA) and Polyethylene glycol (PEG) via the freeze–thaw technique. This starch-citrate hydrogel exhibited excellent antimicrobial activity against various bacteria strains such as Escherichia coli (gram negative), Staphylococcus pyogenes (gram negative), Salmonella thypimurium (gram positive) and Streptococcus aureus (gram positive). Most notably it showed antimicrobial activity against the multiple antibiotic resistant (M.A.R) superbugs (Klebsiella pneumoniae). Penicillin G loaded starch-citrate hydrogel was observed to exhibit a sustain release profile over 7 days. Penicillin G loaded starch-citrate hydrogel also exhibited synergistic antimicrobial activities against Salmonella thypimurium, Escherichia coli (E-coli) (O15:H7) and E-coli control (ATC 2925). The potential application of starch-citrate hydrogel as both antimicrobial agent and drug delivery carriers is therefore envisaged.
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