Effect of aerobic exercise on amyloid accumulation in preclinical Alzheimer’s: A 1-year randomized controlled trial

心肺适能 医学 有氧运动 随机对照试验 痴呆 物理疗法 睡眠剥夺对认知功能的影响 认知 物理医学与康复 内科学
作者
Eric D. Vidoni,Jill K. Morris,Amber Watts,Mark Perry,Jon Clutton,Angela Van Sciver,Ashwini S. Kamat,Jonathan D. Mahnken,Suzanne L. Hunt,Ryan A. Townley,Robyn A. Honea,Ashley R. Shaw,David K. Johnson,James L. Vacek,Jeffrey M. Burns
出处
期刊:PLOS ONE [Public Library of Science]
卷期号:16 (1): e0244893-e0244893 被引量:18
标识
DOI:10.1371/journal.pone.0244893
摘要

Background Our goal was to investigate the role of physical exercise to protect brain health as we age, including the potential to mitigate Alzheimer’s-related pathology. We assessed the effect of 52 weeks of a supervised aerobic exercise program on amyloid accumulation, cognitive performance, and brain volume in cognitively normal older adults with elevated and sub-threshold levels of cerebral amyloid as measured by amyloid PET imaging. Methods and findings This 52-week randomized controlled trial compared the effects of 150 minutes per week of aerobic exercise vs. education control intervention. A total of 117 underactive older adults (mean age 72.9 [7.7]) without evidence of cognitive impairment, with elevated (n = 79) or subthreshold (n = 38) levels of cerebral amyloid were randomized, and 110 participants completed the study. Exercise was conducted with supervision and monitoring by trained exercise specialists. We conducted 18F-AV45 PET imaging of cerebral amyloid and anatomical MRI for whole brain and hippocampal volume at baseline and Week 52 follow-up to index brain health. Neuropsychological tests were conducted at baseline, Week 26, and Week 52 to assess executive function, verbal memory, and visuospatial cognitive domains. Cardiorespiratory fitness testing was performed at baseline and Week 52 to assess response to exercise. The aerobic exercise group significantly improved cardiorespiratory fitness (11% vs. 1% in the control group) but there were no differences in change measures of amyloid, brain volume, or cognitive performance compared to control. Conclusions Aerobic exercise was not associated with reduced amyloid accumulation in cognitively normal older adults with cerebral amyloid. In spite of strong systemic cardiorespiratory effects of the intervention, the observed lack of cognitive or brain structure benefits suggests brain benefits of exercise reported in other studies are likely to be related to non-amyloid effects. Trial registration NCT02000583 ; ClinicalTrials.gov.
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