光热治疗
生物医学中的光声成像
材料科学
等离子体子
吸收(声学)
纳米技术
时域有限差分法
胶体金
纳米医学
纳米颗粒
光电子学
光学
物理
复合材料
作者
Chunyu Zhou,Liang Zhang,Tao Sun,Yang Zhang,Yiding Liu,Mingfu Gong,Zhongsheng Xu,Mengmeng Du,Yun Liu,Gang Liu,Dong Zhang
标识
DOI:10.1002/adma.202006532
摘要
Abstract Precise manipulation of optical properties through the structure‐evolution of plasmonic nanoparticles is of great interest in biomedical fields including bioimaging and phototherapy. However, previous success has been limited to fixed assembled structures or visible–NIR‐I absorption. Here, an activatable NIR‐II plasmonic theranostics system based on silica‐encapsulated self‐assembled gold nanochains (AuNCs@SiO 2 ) for accurate tumor diagnosis and effective treatment is reported. This transformable chain structure breaks through the traditional molecular imaging window, whose absorption can be redshifted from the visible to the NIR‐II region owing to the fusion between adjacent gold nanoparticles in the restricted local space of AuNCs@SiO 2 triggered by the high H 2 O 2 level in the tumor microenvironment (TME), leading to the generation of a new string‐like structure with strong NIR‐II absorption, which is further confirmed by finite‐difference‐time‐domain (FDTD) simulation. With the TME‐activated characteristics, AuNCs@SiO 2 exhibits excellent properties for photoacoustic imaging and a high photothermal conversion efficiency of 82.2% at 1064 nm leading to severe cell death and remarkable tumor growth inhibition in vivo. These prominent intelligent TME‐responsive features of AuNCs@SiO 2 may open up a new avenue to explore optical regulated nano‐platform for intelligent, accurate, and noninvasive theranostics in NIR‐II window.
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