Trial Design and Endpoints in Hepatocellular Carcinoma: AASLD Consensus Conference

HepatologyVolume 73, Issue S1 p. 158-191 Review Trial Design and Endpoints in Hepatocellular Carcinoma: AASLD Consensus Conference Josep M. Llovet, Corresponding Author Josep M. Llovet josep.llovet@mssm.edu orcid.org/0000-0003-0547-2667 Mount Sinai Liver Cancer Program, Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY Translational Research in Hepatic Oncology, Liver Unit, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain Institució Catalana d’Estudis Avançats (ICREA), Barcelona, Spain Address Correspondence and Reprint Requests to: Josep M. Llovet, M.D., Ph.D., F.A.A.S.L.D. Mount Sinai Liver Cancer Program, Division of Liver Diseases Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Madison Avenue 1425, 11F-70, Box 1123 New York, NY 10029 E-mail: josep.llovet@mssm.eduSearch for more papers by this authorAugusto Villanueva, Augusto Villanueva orcid.org/0000-0003-3585-3727 Mount Sinai Liver Cancer Program, Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NYSearch for more papers by this authorJorge A. Marrero, Jorge A. Marrero UT Southwestern Medical Center, Dallas, TXSearch for more papers by this authorMyron Schwartz, Myron Schwartz Mount Sinai Liver Cancer Program, Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NYSearch for more papers by this authorTim Meyer, Tim Meyer Department Oncology, University College London Cancer Institute, London, UKSearch for more papers by this authorPeter R. Galle, Peter R. Galle Department of Internal Medicine, Mainz University Medical Center, Mainz, GermanySearch for more papers by this authorRiccardo Lencioni, Riccardo Lencioni Department of Radiology, University of Pisa School of Medicine, Pisa, Italy Miami Cancer Institute, Miami, FLSearch for more papers by this authorTim F. Greten, Tim F. Greten orcid.org/0000-0002-0806-2535 Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MDSearch for more papers by this authorMasatoshi Kudo, Masatoshi Kudo orcid.org/0000-0002-4102-3474 Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, JapanSearch for more papers by this authorSumithra J. Mandrekar, Sumithra J. Mandrekar Department of Health Sciences Research, Mayo Clinic, Rochester, MNSearch for more papers by this authorAndrew X. Zhu, Andrew X. Zhu orcid.org/0000-0003-4873-5033 Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA Jiahui International Cancer Center, Shanghai, ChinaSearch for more papers by this authorRichard S. Finn, Richard S. Finn Geffen School of Medicine at UCLA, Los Angeles, CASearch for more papers by this authorLewis R. Roberts, Lewis R. Roberts orcid.org/0000-0001-7885-8574 Gastroenterology & Hepatology Department, Mayo Clinic, Rochester, MNSearch for more papers by this author; for the AASLD Panel of Experts on Trial Design in HCC, AASLD Panel of Experts on Trial Design in HCCSearch for more papers by this author Josep M. Llovet, Corresponding Author Josep M. Llovet josep.llovet@mssm.edu orcid.org/0000-0003-0547-2667 Mount Sinai Liver Cancer Program, Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY Translational Research in Hepatic Oncology, Liver Unit, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain Institució Catalana d’Estudis Avançats (ICREA), Barcelona, Spain Address Correspondence and Reprint Requests to: Josep M. Llovet, M.D., Ph.D., F.A.A.S.L.D. Mount Sinai Liver Cancer Program, Division of Liver Diseases Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Madison Avenue 1425, 11F-70, Box 1123 New York, NY 10029 E-mail: josep.llovet@mssm.eduSearch for more papers by this authorAugusto Villanueva, Augusto Villanueva orcid.org/0000-0003-3585-3727 Mount Sinai Liver Cancer Program, Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NYSearch for more papers by this authorJorge A. Marrero, Jorge A. Marrero UT Southwestern Medical Center, Dallas, TXSearch for more papers by this authorMyron Schwartz, Myron Schwartz Mount Sinai Liver Cancer Program, Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NYSearch for more papers by this authorTim Meyer, Tim Meyer Department Oncology, University College London Cancer Institute, London, UKSearch for more papers by this authorPeter R. Galle, Peter R. Galle Department of Internal Medicine, Mainz University Medical Center, Mainz, GermanySearch for more papers by this authorRiccardo Lencioni, Riccardo Lencioni Department of Radiology, University of Pisa School of Medicine, Pisa, Italy Miami Cancer Institute, Miami, FLSearch for more papers by this authorTim F. Greten, Tim F. Greten orcid.org/0000-0002-0806-2535 Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MDSearch for more papers by this authorMasatoshi Kudo, Masatoshi Kudo orcid.org/0000-0002-4102-3474 Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, JapanSearch for more papers by this authorSumithra J. Mandrekar, Sumithra J. Mandrekar Department of Health Sciences Research, Mayo Clinic, Rochester, MNSearch for more papers by this authorAndrew X. Zhu, Andrew X. Zhu orcid.org/0000-0003-4873-5033 Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA Jiahui International Cancer Center, Shanghai, ChinaSearch for more papers by this authorRichard S. Finn, Richard S. Finn Geffen School of Medicine at UCLA, Los Angeles, CASearch for more papers by this authorLewis R. Roberts, Lewis R. Roberts orcid.org/0000-0001-7885-8574 Gastroenterology & Hepatology Department, Mayo Clinic, Rochester, MNSearch for more papers by this author; for the AASLD Panel of Experts on Trial Design in HCC, AASLD Panel of Experts on Trial Design in HCCSearch for more papers by this author First published: 20 May 2020 https://doi.org/10.1002/hep.31327Citations: 139 Potential conflict of interest: Dr. Llovet consults for and received grants from Bayer, Eisai, Ipsen, and Bristol-Myers Squibb. He consults for Merck, Celsion, Eli Lilly, Roche, Genentech, Glycotest, Nucleix, Can-Fite, Sirtex, and AstraZeneca. He received grants from Boehringer Ingelheim. Dr. Villanueva consults for NGM, Gilead, and Nucleix. He advises Fuji Wako and Exact Sciences. Dr. Marrero consults for Glycotest. Dr. Meyer consults for Ipsen, Bristol-Myers Squibb, MSD, Roche, Eisai, and Beigene. He received grants from Bayer and BTG. Dr. Galle consults for, advises, is on the speakers’ bureau for, and received grants from Bayer. He consults for, advises, and is on the speakers’ bureau for AstraZeneca, Bristol-Myers Squibb, Eisai, Ipsen, Eli Lilly, MSD, Roche, and Sirtex. Dr. Kudo consults for, is on the speakers’ bureau for, and received grants from Eisai, Ono, MSD, Bristol-Myers Squibb, Roche, Bayer, EA Pharma, Gilead, Otsuka, Sumitomo, Dainippon, Taiho, Takeda, AbbVie, and Eli Lilly. Dr. Zhu advises Eli Lilly, Bayer, Eisai, Merck, Sanofi, Exelixis, and Roche. Dr. Finn consults for AstraZeneca, Bayer, CStone, Bristol-Myers Squibb, Eisai, Eli Lilly, Pfizer, Merck, Novartis, Genentech, and Roche. Dr. Roberts advises and received grants from Bayer, Exact Sciences, and Gilead. He advises GRAIL, QED, and TAVEC. He received grants from BTG, Glycotest, RedHill, TARGET, and Wako. 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