材料科学
纳米技术
药物输送
仿生材料
生物相容性
体内
生化工程
生物医学工程
生物技术
生物
工程类
冶金
作者
Changyong Gao,Yong Wang,Zihan Ye,Zhihua Lin,Xing Ma,Qiang He
标识
DOI:10.1002/adma.202000512
摘要
Abstract Self‐propelled micro‐ and nanomotors (MNMs) have shown great potential for applications in the biomedical field, such as active targeted delivery, detoxification, minimally invasive diagnostics, and nanosurgery, owing to their tiny size, autonomous motion, and navigation capacities. To enter the clinic, biomedical MNMs request the biodegradability of their manufacturing materials, the biocompatibility of chemical fuels or externally physical fields, the capability of overcoming various biological barriers (e.g., biofouling, blood flow, blood–brain barrier, cell membrane), and the in vivo visual positioning for autonomous navigation. Herein, the recent advances of synthetic MNMs in overcoming biological barriers and in vivo motion‐tracking imaging techniques are highlighted. The challenges and future research priorities are also addressed. With continued attention and innovation, it is believed that, in the future, biomedical MNMs will pave the way to improve the targeted drug delivery efficiency.
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