皮质骨
抗弯刚度
生物力学
骨矿物
骨密度
内科学
化学
内分泌学
刚度
解剖
材料科学
生物
医学
骨质疏松症
复合材料
作者
Aysha B. Khalid,Simon R. Goodyear,Ruth A. Ross,R.M. Aspden
标识
DOI:10.1016/j.medengphy.2016.06.024
摘要
The endocannabinoid system is known for its regulatory effects on bone metabolism through the cannabinoid receptors, Cnr1 and Cnr2. In this study we analysed the mechanical and material properties of long bones from Cnr1−/− mice on a C57BL/6 background. Tibiae and femora from 5- and 12-week-old mice were subjected to three-point bending to measure bending stiffness and yield strength. Elastic modulus, density and mineral content were measured in the diaphysis. Second moment of area (MOA2), inner and outer perimeters of the cortical shaft and trabecular fractional bone volume (BV/TV) were measured using micro-CT. In Cnr1−/− males and females at both ages the bending stiffness was reduced due to a smaller MOA2. Bone from Cnr1−/− females had a greater modulus than wild-type controls, although no differences were observed in males. BV/TV of 12-week-old Cnr1−/− females was greater than controls, although no difference was seen at 5-weeks. On the contrary, Cnr1−/− males had the same BV/TV as controls at 12-weeks while they had significantly lower values at 5-weeks. This study shows that deleting Cnr1 decreases the amount of cortical bone in both males and females at 12-weeks, but increases the amount of trabecular bone only in females.
科研通智能强力驱动
Strongly Powered by AbleSci AI