缺氧诱导因子
缺氧(环境)
阿尔法(金融)
内科学
HIF1A型
心脏病学
血管生成
癌症研究
作者
Satwat Hashmi,Suhail Al-Salam
出处
期刊:Cardiology in Review
[Ovid Technologies (Wolters Kluwer)]
日期:2012-11-01
卷期号:20 (6): 268-273
被引量:18
标识
DOI:10.1097/crd.0b013e31826287f6
摘要
Hypoxia-inducible factor (HIF) is a set of transcription factors that regulate the cellular response to hypoxia. There is a great body of evidence supporting the protective role of HIF-1α in cardiovascular pathophysiology, however, newer studies are hinting at a maladaptive and deleterious role of this transcription factor that merits further investigation. There is a general agreement, however, that HIF-mediated responses appear to differ under conditions of acute and chronic oxygen deprivation. The intensity and sustainability of HIF-1α activation are major determinants of whether the responses are pathological or beneficial. HIF activation is seen to be beneficial in the setting of acute myocardial ischemia and deleterious in chronic conditions. In this review, we will focus on recent insights into the role of HIF-1α in the heart and especially in the setting of ischemic heart disease.
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