There are different oil products in running of sequential transportation pipeline, and these branch pipelines are used to subtract some oil from the main pipeline or trickle some oil into the main pipeline due to the different demand between different regions. When these branch pipelines work, the flow velocity and pressure in the main pipeline behind the branches will change. In this paper, the software was used to simulate the examples, effect of branch pipelines running on the main pipeline was analyzed, which could provide theoretical basis for planning sequential transportation scheme.