[BT(2+2]Early enteral application of probiotics improved the changes of inflammatory mediators and its relationship with the prognosis in the patients with severe acute pancreatitis

Objective:To observe the changes in serum interleukin-8(IL-8) and tumor necrosis factor-α(TNF-α) in the patients with severe acute pancreatitis followed early enteral probiotics(EEP) compared with early enteral nutrition(EEN) and its possible mechanism of effect on prognosis.Methods:Fourty-five patients with severe pancreatitis were randomized equally into two groups(EEP group,n=20 and EEN group,n=25) which received standard therapeutic procedures except the use of probiotics.Serum IL-8 and TNF-α were measured pretherapy,7th day,and 14th day by ELISA.The blood amylase and WBC account were also monitored at the same time.Patients' prognoses with SAP were observed.Results:At 7th and 14th day after EEP and EEN,all the inflammatory mediators decreased,but the EEP group offered significant differences compared with EEN groups on 14th day(P0.05).And the Amylase level and WBC account showed the similar results between two groups on 14th day.GI function score showed EEP group was better than EEN group.For EEP group,the infection peripancreas and upper GI bleeding seemed lower than that of EEN group.Conclusion:Early enteral use of probiotics in the patients with SAP could significantly decrease the level of inflammatory mediators and improved the patients' prognoses.Early enteral use of probiotics might maintain the GI barrier,inhibit the bacteria translocation and improve the GI tract host defense ability which plays an important role in SAP patients' recovery and further investigation is needed.