重离子
细胞凋亡
线性能量转移
辐照
离子
脑细胞
相对生物效应
脑功能
细胞存活
化学
生物
放射化学
分子生物学
细胞生物学
物理
生物化学
神经科学
核物理学
有机化学
作者
Kumie Nojima,Taeko Nakadai,Yukio Kohno,Marcelo E. Vazquez,N. Yasuda,Shunji Nagaoka
出处
期刊:PubMed
日期:2004-11-01
卷期号:18 (3): 114-5
被引量:1
摘要
To investigate effects of low dose heavy particle radiation to CNS system, we adopted mouse neonatal brain cells in culture being exposed to heavy ions by HIMAC at NIRS and NSRL at BNL. The applied dose varied from 0.05 Gy up to 2.0 Gy. The subsequent biological effects were evaluated by an induction of apoptosis and neuron survival focusing on the dependencies of the animal strains, SCID, B6, B6C3F1, C3H, used for brain cell culture, SCID was the most sensitive and C3H the least sensitive to particle radiation as evaluated by 10% apoptotic criterion. The LET dependency was compared with using SCID and B6 cells exposing to different ions (H, C, Ne, Si, Ar, and Fe). Although no detectable LET dependency was observed in the high LET (55-200 keV/micrometers) and low dose (<0.5 Gy) regions. The survivability profiles of the neurons were different in the mouse strains and ions. In this report, a result of memory and learning function to adult mice after whole-body and brain local irradiation at carbon ion and iron ion.
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