α-螺旋跨膜蛋白的折叠和自组装

Given the critical roles of membrane proteins in cellular processes ranging from signal transduction to immune response, as well as the significance of these proteins as drug targets, efforts to understand their structures and functions are vital for human health and diseases. α-Helix transmembrane protein is a significant and common membrane protein. This paper reviews? the recent progress of its folding and self-assembly, presenting an overview of the two-stage model and structural bases for transmembrane association and introducing the novel chemical and biological method for the studies of folding and self-assembly of α-helix transmembrane protein.