A Simple and Rapid Hplc Method for the Determination of Mitotane in Human Plasma and a Case of Adrenal Cancer

Background: Mitotane is used for the treatment of adrenal cancer and inoperable Cushing's syndrome.Previous studies show that monitoring of the plasma mitotane level is important for increasing efficacies and reducing adverse events such as digestive symptoms.Plasma concentration of 14 ∼ 20 µg/ml are considered therapeutic level.