斑马鱼
生物
心脏发育
形态发生
模式生物
细胞生物学
计算生物学
突变体
遗传学
基因
胚胎干细胞
作者
David Staudt,Didier Y. R. Stainier
出处
期刊:Annual Review of Genetics
[Annual Reviews]
日期:2012-12-15
卷期号:46 (1): 397-418
被引量:214
标识
DOI:10.1146/annurev-genet-110711-155646
摘要
Over the past 20 years, the zebrafish has emerged as a powerful model organism for studying cardiac development. Its ability to survive without an active circulation and amenability to forward genetics has led to the identification of numerous mutants whose study has helped elucidate new mechanisms in cardiac development. Furthermore, its transparent, externally developing embryos have allowed detailed cellular analyses of heart development. In this review, we discuss the molecular and cellular processes involved in zebrafish heart development from progenitor specification to development of the valve and the conduction system. We focus on imaging studies that have uncovered the cellular bases of heart development and on zebrafish mutants with cardiac abnormalities whose study has revealed novel molecular pathways in cardiac cell specification and tissue morphogenesis.
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