殖民抵抗
病菌
免疫系统
生物
寄主(生物学)
肠道菌群
胃肠道
免疫学
肠道病毒
殖民地化
炎症
微生物学
粪便
微生物群
失调
医学
小肠
细菌
生态学
生物化学
作者
Inna Sekirov,B. Brett Finlay
标识
DOI:10.1113/jphysiol.2009.172742
摘要
The consortia of microorganisms inhabiting the length of the gastrointestinal tract, the gastrointestinal microbiota, are vital to many aspects of normal host physiology. In addition, they are an active participant in the progression of many diseases, among them enteric infections. Healthy intestinal microbiota contribute to host resistance to infection through their involvement in the development of the host immune system and provision of colonization resistance. It is not surprising then that disruptions of the microbial community translate into alterations of host susceptibility to infection. Additionally, the process of the infection itself results in a disturbance to the microbiota. This disturbance is often mediated by the host inflammatory response, allowing the pathogen to benefit from the inflammation at the intestinal mucosa. Uncovering the mechanisms underlying the host-pathogen-microbiota interactions will facilitate our understanding of the infection process and promote design of more effective and focused prophylactic and therapeutic strategies.
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