DNA损伤
生殖毒性
秀丽隐杆线虫
细胞生物学
生物
毒性
表观遗传学
信号转导
细胞凋亡
机制(生物学)
DNA
化学
遗传学
基因
认识论
哲学
有机化学
作者
Yunli Zhao,Qiuli Wu,Dayong Wang
出处
期刊:Biomaterials
[Elsevier]
日期:2016-02-01
卷期号:79: 15-24
被引量:119
标识
DOI:10.1016/j.biomaterials.2015.11.052
摘要
Although many studies have suggested the adverse effects of engineered nanomaterials (ENMs), the self-protection mechanisms for organisms against ENMs toxicity are still largely unclear. Using Caenorhabditis elegans as an in vivo assay system, our results suggest the toxicity of graphene oxide in reducing reproductive capacity by inducing damage on gonad development. The observed reproductive toxicity of GO on gonad development was due to the combinational effect of germline apoptosis and cell cycle arrest, and DNA damage activation might act as an inducer for this combinational effect. For the underlying molecular mechanism of reproductive toxicity of GO, we raised a signaling cascade of HUS-1/CLK-2-CEP-1-EGL-1-CED-4-CED-3 to explain the roles of core apoptosis signaling pathway and DNA damage checkpoints. Moreover, we identified a miRNA regulation mechanism activated by GO to suppress its induced reproductive toxicity. A mir-360 regulation mechanism was activated by GO to suppress its induced DNA damage-apoptosis signaling cascade through affecting component of CEP-1. Our identified epigenetic signal encoded protection mechanism activated by GO suggests a novel self-protection mechanism for organisms against the ENMs toxicity.
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