化学
金鸡纳
羟基化
生物碱
产量(工程)
对映体
催化作用
有机化学
对映选择合成
立体化学
材料科学
冶金
酶
作者
Yakun Wang,Hang Yin,Hai Qing,Jingnan Zhao,Yufeng Wu,Qingwei Meng
标识
DOI:10.1002/adsc.201500911
摘要
Abstract The highly catalytic asymmetric α‐hydroxylation of β‐indanone esters and β‐indanone amides using peroxide as the oxidant was realized with a new C‐2′ substituted Cinchona alkaloid derivatives. The two enantiomers of α‐hydroxy‐β‐indanone esters could be obtained by simply changing the oxidant. This protocol allows a convenient access to the corresponding α‐hydroxy‐β‐indanone esters and α‐hydroxy‐β‐indanone amides with up to 99% yield and 98% ee . magnified image
科研通智能强力驱动
Strongly Powered by AbleSci AI