光热治疗
生物相容性
纳米颗粒
纳米技术
光热效应
材料科学
纳米棒
涂层
生物相容性材料
化学
纳米材料
生物医学工程
医学
冶金
作者
Xijian Liu,Bo Li,Fanfan Fu,Kaibing Xu,Rujia Zou,Qian Wang,Bingjie Zhang,Zhigang Chen,Junqing Hu
出处
期刊:Dalton Transactions
[The Royal Society of Chemistry]
日期:2014-05-27
卷期号:43 (30): 11709-11709
被引量:225
摘要
The semiconductor compounds have been proven to be promising candidates as a new type of photothermal therapy agent, but unsatisfactory photothermal conversion efficiencies limit their widespread application in photothermal therapy (PTT). Herein, we synthesized cysteine-coated CuS nanoparticles (Cys-CuS NPs) as highly efficient PTT agents by a simple aqueous solution method. The Cys-CuS NPs have a good biocompatibility owing to their biocompatible cysteine coating and exhibit a strong absorption in the near-infrared region due to the localized surface plasma resonances of valence-band free carriers. The photothermal conversion efficiency of Cys-CuS NPs reaches 38.0%, which is much higher than that of the recently reported Cu9S5 and Cu2−xSe nanocrystals. More importantly, tumor growth can be efficiently inhibited in vivo by the fatal heat arising from the excellent photothermal effect of Cys-CuS NPs at a low concentration under the irradiation of a 980 nm laser with a safe power density of 0.72 W cm−2. Therefore, the Cys-CuS NPs have great potential as ideal photothermal agents for cancer therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI