Trophoblast organoid systems to study human placentation

Human trophoblast organoids provide a valuable in vitro system to investigate human placental development and function. In this issue of Developmental Cell, Shannon et al. benchmark two organoid models against primary trophoblast at single-cell resolution, identifying their strengths and limitations. Human trophoblast organoids provide a valuable in vitro system to investigate human placental development and function. In this issue of Developmental Cell, Shannon et al. benchmark two organoid models against primary trophoblast at single-cell resolution, identifying their strengths and limitations. Single-cell assessment of primary and stem cell-derived human trophoblast organoids as placenta-modeling platformsShannon et al.Developmental CellFebruary 14, 2024In BriefAlthough the merits of trophoblast organoids have been established, a high-resolution assessment of these systems has not been performed. Here, Shannon et al. generate a single-cell transcriptomic atlas of two distinct trophoblast organoid systems that defines their similarities and discrepancies with reference to in vivo trophoblasts. Full-Text PDF