In-vivo Assessment of Cellular Soma and Neurite Density Abnormalities in Multiple Sclerosis Paramagnetic Rim and Core-sign Lesions (P11-6.006)

Using soma and neurite density imaging (SANDI) method based on diffusion-weighted MRI, we characterized in vivo the microstructural abnormalities of multiple sclerosis (MS) white matter lesions (WML) showing a paramagnetic rim (paramagnetic rim lesions [PRL]) or diffuse hypointensity ("core-sign") on susceptibility-weighted imaging (SWI) and their clinical relevance.