Anti-inflammatory monomeric sorbicillinoids from the marine-fish- derived fungus Trichoderma sp. G13

Four new monomeric sorbicillinoids, trichillinoids A − D (1–4), along with two known dimeric sorbicillinoids (5 and 6), and five known monomeric sorbicillinoids (7–11), were obtained from the marine-fish-derived fungus Trichoderma sp. G13. They were structurally characterized on the basis of comprehensive spectroscopic investigations (NMR, HRESIMS, and ECD). Compounds 1–4 displayed moderate anti-inflammatory activities, according to inhibiting the production of NO in RAW264.7 cells activated with IC50 values ranging from 14 to 20 μM.