Abstract The detection of environmental gases in the atmosphere is a topic of interest for public security, environmental pollution and industrial emission. In recent years, semiconductor-based gas sensor attracted wide attention in all over the world. Among various hazardous gases, detection of CO at low temperature with fast response and recovery time is still a challenge. In this work, we have adopted single step synthesis of zinc oxide (ZnO) nanoroads for the fabrication of CO gas sensor. This sensor is found to have ~8% sensitivity with fast response time of the order of 10s at 50C. Also, selectivity of these sensors has been investigated for different gases and observed that ZnO are more active for CO gas at 50C. The sensitivity of ZnO based sensor is explained in terms of interaction of CO molecules with adsorbed oxygen vacancies in ZnO which promote better pathway to the charge carrier. The sensing material was characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). To, the best our knowledge, the detection of 15 ppm CO at 50 with good sensitivity is reported first time.