Preparation, Characterization and In vitro Evaluation of Insulin-PHBV Nanoparticles / Alginate Hydrogel Composite System for Prolonged Delivery of Insulin

In the present study, biodegradable poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles (NPs) containing insulin were loaded in sodium alginate/jeffamine (ALG/jeff) hydrogel for prolonged delivery of insulin. The main aim of this work was to fabricate an efficient insulin delivery system to improve patient adherence by decreasing the repetition of injections.