化学
流动化学
杜鲁特格拉维尔
连续流动
活性成分
产量(工程)
组合化学
化学合成
工艺工程
人类免疫缺陷病毒(HIV)
有机化学
生化工程
热力学
催化作用
医学
生物信息学
生物化学
物理
家庭医学
抗逆转录病毒疗法
病毒载量
工程类
体外
生物
作者
Sinazo Nqeketo,Paul Watts
标识
DOI:10.1021/acs.joc.3c01365
摘要
An efficient continuous flow process for the synthesis of dolutegravir, an active pharmaceutical ingredient (API) for HIV treatment, was investigated. The synthetic procedure starts from a readily available benzyl-protected pyran via six chemical transformations using continuous flow reactors. The significant advantage of this flow process includes the reduction of the overall reaction time from 34.5 h in batch to 14.5 min. The overall yield of each reaction step improved dramatically upon flow optimization. Another key feature of this synthesis is telescoping multiple steps.
科研通智能强力驱动
Strongly Powered by AbleSci AI