Right lateral orbitofrontal cortex inhibitory transcranial magnetic stimulation for treatment of refractory mood and depression

High-frequency repetitive Transcranial Magnetic Stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) is an effective treatment for Major Depressive Disorder (MDD), but up to half of patients can have significant residual depressive symptoms using this treatment approach [1]. Developing new approaches to enhance rTMS treatment efficacy is critically important considering that the majority of patients pursue rTMS only after failing to respond to available pharmacological and psychotherapeutic treatment options.