医学
四分位间距
狼牙棒
危险系数
内科学
累积发病率
心肌梗塞
置信区间
队列
心绞痛
回顾性队列研究
冲程(发动机)
比例危险模型
心脏病学
经皮冠状动脉介入治疗
工程类
机械工程
作者
Zhiwen Xiao,Tengfei Long,Lin Xu,Wenlong Xu,Haoxiang Huang,Yuegang Wang,Shiping Cao,Zhen Xie,Wangjun Liao,Yulin Liao,Jianping Bin,Weijing Feng,Yanmei Chen
标识
DOI:10.1093/eurjpc/zwad297
摘要
Abstract Aims Remnant cholesterol (RC) reportedly mediates residual cardiovascular risk in atherosclerotic cardiovascular diseases (ASCVD). However, few studies have characterized long-term cumulative RC exposure among elderly people. The study aimed to evaluate the association between cumulative exposure to RC and incident major adverse cardiovascular events (MACE) by analysing a cohort of elderly patients with ASCVD. Methods and results This retrospective multicentre cohort study enrolled ASCVD participants aged ≥75 years with baseline visits occurring from 2006 to 2012 followed by four in-person visits. Cumulative RC was estimated as the area under the curve using measurements from the first to fourth visits by using 9-year data. The time-weighted average (TWA) RC was expressed as cumulative exposure to RC averaged by years. All outcomes were follow-up from the fourth visit to the year 2021. Outcomes included a composite of MACE (stroke, unstable angina pectoris, myocardial infarction, and cardiac death). We included 4,680 participants (73.1% male, mean age 79.3 ± 2.5 years). The median follow-up duration was 6.1 years (interquartile range: 3.4–6.6 years). In the multivariable model adjusted for traditional cardiovascular risk factors, low-density lipoprotein cholesterol level, and most recent RC level, the hazard ratios for MACE that compared the high and low tertiles of the RC variables were 1.30 [95% confidence interval (CI), 1.16–1.44] for cumulative RC and 1.36 (95% CI, 1.23–1.52) for TWA RC. Consistent significant associations were observed among most propensity score analyses. Conclusions Long-term cumulative RC was independently associated with incident MACE in elderly participants with ASCVD, suggesting that achieving and maintaining optimal RC levels later in life may still improve cardiovascular outcomes.
科研通智能强力驱动
Strongly Powered by AbleSci AI